中国社区医师2016，Vol.32Issue(24)：7-9,11,4.DOI:10.3969/j.issn.1007-614x.2016.24.1
新纤维化相关因子SFTPA2与UUO模型大鼠肾间质纤维化关系的研究
Study on the relationship between new fibrosis related factor SFTPA2 and the renal interstitial fibrosis of UUO model rats
摘要
Abstract
Objective:To observe the dynamic progression of renal tubule interstitial fibrosis of unilateral ureteral obstruction(UUO) model rats,to study the relationship between new fibrosis related factor SFTPA2 and rat renal interstitial fibrosis. Methods:64 SD rats were randomly divided into the unilateral ureteral obstruction model group(UUO),the sham operation group(NC),the siRNA group(the gene silencing group) and the negative control group.The renal tubular interstitial fibrosis degree was evaluated.The SFTPA2 expression of the obstructive nephropathy renal tissue was detected.The rats blood SFTPA2 and TGF-β1 contents were detected.The relationship between SFTPA2 and obstructive renal interstitial fibrosis was analyzed.Results:Compared with the sham operation group,with the extension of rat ureter obstruction time,the renal tubule interstitial fibrosis degree gradually increased,the SFTPA2 expression and blood SFTPA2 and TGF-β1 contents of renal interstitium also increased. After the interdiction of SFTPA2,SFTPA2 and TGF-β 1 expressions were also reduced.Conclusion:Renal interstitial fibrosis related factor SFTPA2 may be involved in the process of renal interstitial fibrosis in UUO model rats.关键词
肾间质纤维化/单侧输尿管梗阻/SFTPA2/转化生长因子-β1Key words
Renal interstitial fibrosis/unilateral ureteral obstruction/SFTPA2/Transforming growth factor-β1引用本文复制引用
茶春丽,代留玲,陈国姝,李靖娟,李俊..新纤维化相关因子SFTPA2与UUO模型大鼠肾间质纤维化关系的研究[J].中国社区医师,2016,32(24):7-9,11,4.基金项目
云南省应用基础研究计划项目(2012FB029)，昆明医科大学创新基金项目(2015S23)Fund project Yunnan Province Applied Basic Research Plan Project(2012FB029),Kunming Medical University Innovation Fund Project(2015S23) （2012FB029）
