中国医学创新2016，Vol.13Issue(21)：1-4,4.DOI:10.3969/j.issn.1674-4985.2016.21.001
关节液中TNF-α、IL-1、MMPS水平对膝骨性关节炎患者的预后的评估价值
Value of TNF-α,IL-1 and MMPS Levels in the Evaluation of Prognosis of Patients with Knee Osteoarthritis
摘要
Abstract
Objective:To investigate the relationship between TNF-α,IL-1,MMPs levels and prognosis evaluation value in patients with knee osteoarthritis.Method:From January 2012 to February 2015, 80 cases of knee osteoarthritis identified by arthroscopy in our hospital were selected as the research objects,the degree of cartilage lesions including Ⅰ-Ⅳ degree,they were given sodium hyaluronate and diacerein treated after arthroscopic debridement,patients were divided into good prognosis group and poor prognosis group according to the shahariarre scoring criteria,the content of TNF-α,IL-1,MMP-3 and MMP-9 before and after treatment were detected by ELISA method and Spearman correlation analysis were used to detect degree of pathological changes of knee osteoarthritis,the prognostic value of TNF-α,IL-1,MMP-9 and MMP-3 in patients with knee osteoarthritis were evaluated by ROC curve.Result:The content of TNF-α,IL-1,MMP-3 and MMP-9 before treatment was positively correlated with the severity of the lesion(r=0.820,0.850,0.802,0.638,P<0.01). TNF-α,IL-1,MMP-3 and MMP-9 levels of good prognosis group were significantly lower than the poor prognosis group,the differences were statistically significant(P<0.01).TNF-α,IL-1,MMP-3 and MMP-9 content of the area under the ROC curve were respectively 0.880,0.895,0.752 and 0.720.IL-1 sensitivity was 94.00%and specificity was 64.00%.TNF-α sensitivity was 87.00% and specificity was 56.00%.MMP-3 sensitivity was 79.00%and specificity was 42.00%.MMP-9 sensitivity was 70.00% and specificity was 38.00%.Conclusion:The effect of IL-1 on knee osteoarthritis is the whole,can enhance the degradation and destruction of cartilage in patients with MMP-3 and MMP-9.TNF-α can reduce the synthesis of cartilage cells and accelerate the degradation of cartilage,the content of TNF-α,IL-1,MMP-3 and MMP-9 are positively correlated with the extent of the lesion,have a certain value of assessment for patients with prognosis evaluation.关键词
膝骨性关节炎/TNF-α/IL-1/预后Key words
Knee osteoarthritis/TNF-α/IL-1/Prognosis引用本文复制引用
何启荣,林伟文..关节液中TNF-α、IL-1、MMPS水平对膝骨性关节炎患者的预后的评估价值[J].中国医学创新,2016,13(21):1-4,4.基金项目
广东省佛山市医学类科技攻关项目 （）
