中国医学创新2016，Vol.13Issue(21)：5-8,9,5.DOI:10.3969/j.issn.1674-4985.2016.21.002
VEGF和SLeX表达与甲状腺乳头状癌浸润转移的关系
Expressions of VEGF and SLeX in Papillary Thyroid Carcinoma and Their Relationships with Invasion and Metastasis
李永庆 1尚培中 1柳勇 1张星光 2张进权 3南润玲 1谷化平1
作者信息
- 1. 中国人民解放军第251医院 河北 张家口 075000
- 2. 中国人民解放军陆军总医院
- 3. 河北省蔚县人民医院
- 折叠
摘要
Abstract
Objective:To investigate the expressions of VEGF and SLeX in papillary thyroid carcinoma and their relationships with the potential of invasion and metastasis.Method:The expressions of VEGF and SLeX in 164 cases of papillary thyroid carcinoma and 30 cases of para-tumorous tissue were studied by EliVisionTM plus two-step immunohistochemical method.Result:The positive rates of VEGF and SLeX in papillary thyroid carcinoma were 59.8%(98/164)and 70.7%(116/164),both were significantly higher than those in para-tumorous tissue (P<0.05).The positive rates of VEGF and SLeX in the patients with tumor invasion were 69.7%(69/99)and 84.8%(84/99),both were significantly higher than those in without tumor invasion(P<0.05).The positive rates of VEGF and SLeX in the patients with lymphatic metastasis were 69.9%(65/93)and 89.2%(83/93),both were significantly higher than those in without lymphatic metastasis(P<0.05).There was a positive correlation between VEGF and SLeX expression(r=0.59).Conclusion:High level expressions of VEGF and SLeX in papillary thyroid carcinoma are closely correlated with the invasive and metastasic potential.关键词
甲状腺肿瘤/VEGF/SLeX/浸润/转移Key words
Thyroid neoplasms/VEGF/SLeX/Invasion/Metastasis引用本文复制引用
李永庆,尚培中,柳勇,张星光,张进权,南润玲,谷化平..VEGF和SLeX表达与甲状腺乳头状癌浸润转移的关系[J].中国医学创新,2016,13(21):5-8,9,5.
