摘要
Abstract
Objective:To investigate the oxidative stress and curative effects of fluimucil in treating Asthma-COPD overlap syndrome(ACOS).Method:A total of 60 patients with stable ACOS from June 2012 to June 2014 in our hospital patients(ACOS group) and 60 healthy smokers in the same period in our hospital physical examination center (the control group) were selected.ACOS group was randomly divided into routine treatment group and antioxidant treatment group.Routine treatment group received simple inhalation of Glucocorticoid/Long-actingβ2 Receptor Agonist(Salmeterol/Fluorine Fluticasone Propionate Powder for Inhalation 50/500μg, two times a day),while antioxidant treatment group added the N acetylcysteine 600 mg twice/day based on routine treatment group.The course of treatment was 3 months.Pulmonary function tests,bronchial dilation test,arterial blood gas analysis,and serum MDA,GSH content,SOD activity were performed before and after treatment in all testers.Result:Compared with the control group,serum MDA,and GSH content in serum of ACOS group were significantly higher,the activity of superoxide dismutase(SOD) of ACOS group compared with the control group was decreased significantly(P<0.05).ACOS group serum MDA and FEV1 significantly negative correlation(P<0.05),and GSH content in serum,SOD activity and FEV1 significantly positive correlation (P<0.05).Routine treatment group and Antioxidant treatment group before and after treatment,serum MDA decreased,and GSH content in serum,SOD activity and FEV1 rose(P<0.05).Antioxidant treatment group,the serum levels of MDA decreased and GSH content in serum,SOD activity and FEV1 increased amplitude compared with routine treatment group significantly(P<0.05).Conclusion:ACOS patients have systemic oxidation/antioxidant imbalance,and the imbalance are related to the decline in lung function.N-acetyl cysteine oxidation treatment can improve ACOS patients systemic oxidation/antioxidant imbalance,so as to improve their lung function.关键词
哮喘-慢性阻塞性肺疾病重叠综合征/氧化应激/乙酰半胱氨酸片/肺功能/丙二醛/超氧化物歧化酶/还原型谷胱甘肽Key words
Asthma-COPD overlap syndrome/Oxidative stress/Acetylcysteine Tablets/Pulmonary function/Malondialdehyde/Superoxide dismutase/Glutathione Peroxidase
