中国医学创新2016，Vol.13Issue(23)：24-26,27,4.DOI:10.3969/j.issn.1674-4985.2016.23.007
酮咯酸氨丁三醇和罗哌卡因合用对小鼠创口愈合的影响
Effects of Ketorolac Tromethamine Combine with Ropivacaine on Wound Healing in Mice
李鑫焱 1程桥 1凡浙录 1张恒海 1张倩1
作者信息
摘要
Abstract
Objective:To study the effect of ketorolac tromethamine and ropivacaine on the expression of GM-CSF involved in wound healing.Method:The 128 healthy adult male Kunming mice,cleaning grade, were randomly divided into four groups and group D assigned to be injected intraperitoneally Saline with a equal dose 0.1 mL/(kg·12 h).Group L injected 0.5% Ropivacaine 1 mL/(kg·12 h) around the cut.N group intraperitoneally Ketorolac Tromethamine 5 mg/(kg·12 h).Group H injected Ropivacaine 1 mL/(kg·12 h) around the cut combineing with intraperitoneally Ketorolac Tromethamine 5 mg/(kg·12 h),respectively,in 12 hours.After the completion of the incision in mice models,we randomly selected eight mice without being putted back from every group at the 3rd,the 7th and the 10th day,then measured the expression of GM-CSF by Elisa. The rest 8 mice in the every group would be continued to feed to heal completely in order to record the time that the wound healing takes and observe the intertion status.Result:The expression of GM-CSF between group H and D were compared,group H was higher at 7th ,10th day(P<0.05).The healing time of group H was shorter than that of group D(P<0.05).The area of scar in the group H was smaller than group L(P<0.05),compared with group D,the difference was statistically significant(P<0.05).Conclusion:Ropivacaine combining with Ketorolac Tromethamine can increase the expression of GM-CSF and promote the healing of wound without causing the excessive scar hyperplasia.关键词
酮咯酸氨丁三醇/罗哌卡因/伤口愈合Key words
Ketorolac Tromethamine/Ropivacaine/Wound healing引用本文复制引用
李鑫焱,程桥,凡浙录,张恒海,张倩..酮咯酸氨丁三醇和罗哌卡因合用对小鼠创口愈合的影响[J].中国医学创新,2016,13(23):24-26,27,4.
