中国卒中杂志2016，Vol.11Issue(7)：530-535,6.DOI:10.3969/j.issn.1673-5765.2016.07.003
脑白质疏松伴认知障碍患者静息态功能磁共振成像研究
Resting-state Functional Magnetic Resonance Imaging Study of Leukoaraiosis Patients with Cognitive Impairment
摘要
Abstract
Objective To investigate the differences in the resting state network between patients with cognitive impairment related leukoaraiosis and normal control. Methods A total of 40 patients with leukoaraiosis related cognitive impairment diagnosed by iconographic and clinical diagnosis and 30 normal controls were included in this study. The resting-state functional magnetic resonance imaging was scanned. All subjects of the two groups were matched in age, gender and level of education. The independent component analysis was used to deal with the data, and the two-samplet-test was used to compare the differences between the two groups. Results Compared with the normal control group, leukoaraiosis patients with cognitive impairment showed significantly decreased activation at bilateral precuneus, left inferior temporal gyrus, left fusiform gyrus and right anterior cingulate; increased activation at left paracentral lobule and right cuneus; signiifcantly increased activation at left superior temporal gyrus; and signiifcantly decreased activation at bilateral cuneus, middle occipital gyrus and left lingual gyrus. Conclusion There were many differences in resting-state functional brain network between patients with cognitive impairment related leukoaraiosis and normal control.关键词
脑白质疏松/认知障碍/静息态功能磁共振/静息态网络Key words
Leukoaraiosis/Cognitive impairment/Resting-state functional magnetic resonance imaging/Resting-state functional brain network引用本文复制引用
沈慧聪,常天静,詹炯,李越秀,张玉梅,张宁,王春雪,马军..脑白质疏松伴认知障碍患者静息态功能磁共振成像研究[J].中国卒中杂志,2016,11(7):530-535,6.基金项目
首都临床特色应用研究（Z151100004015127）北京市自然科学基金 （）
