中国卒中杂志2016，Vol.11Issue(7)：547-555,9.DOI:10.3969/j.issn.1673-5765.2016.07.006
静脉回流障碍与短暂性全面遗忘症的相关性
Obstruction of Venous Drainage Linked toTransient Global Amnesia
韩珂 1赵雅琴 2张丰基 3钟芷萍 4许弘毅 5盛文鸯 4吴江 1胡汉华6
作者信息
- 1. 130021 长春吉林大学白求恩第一医院神经内科 神经科学中心
- 2. 高雄医科大学医学院神经内科 高雄医科大学附属医院神经内科
- 3. 台北阳明大学；台北荣民总医院放射线科
- 4. 台北阳明大学 台北荣民总医院神经内科
- 5. 台中中山医科大学医学院神经内科 台中童综和医院神经内科
- 6. 台北台北医科大学医学院临床医学研究所 台北医科大学医学院脑血管病治疗与研究中心 台北医科大学双和医院神经内科
- 折叠
摘要
Abstract
Abnormal extracranial venous drainage modality has been considered an etiology of transient global amnesia (TGA). Evidence suggests that the transmission of the intrathoracic/intraabdominal pressure during a Valsalva maneuver (VM) is mainly through the vertebral venous system, and patency of internal jugular vein (IJV) is essential for venous drainage and pressure releasing. We hypothesize that obstruction of IJV venous drainage is a contributing factor in TGA pathogenesis. A magnetic resonance imaging (MRI) protocol was used in 45 TGA patients and 45 age- and sex-matched controls to assess the morphologies of IJV, brachiocephalic vein (BCV) and asymmetry of transverse sinus (TS). The IJV was divided into the upper- and middle-IJV segments. Compared to the controls, TGA patients had significantly higher rates of moderate and severe compression/stenosis at the bilateral upper-IJV segment (left: 37.8%vs 17.8%,P=0.0393; right: 57.8%vs 15.6%,P<0.0012), in left BCV (60%vs 8.9%,P<0.0004),and in TS hypoplasia (53.3%vs 31.1%,P=0.0405). The prevalence of at least one site of venous compression/stenosis in IJV or BCV was signiifcantly higher in patients than in controls (91.1%vs 33.3%,P<0.0004). The diameter of the left TS in MRV, but not in T1 contrast imaging, was signiifcantly smaller in TGA patients than in controls (0.31±0.21vs 0.41±0.19,P=0.0290), which was compatible with downstream venous stenosis/obstruction. TGA patients have a higher prevalence of compression/stenosis of the bilateral IJV and the left BCV and TS hypoplasia, which is new evidence that supports the role of extracranial veins in TGA pathogenesis.关键词
短暂性全面遗忘症/颈内静脉/头臂静脉/横窦发育不良/Valsalva动作Key words
Transient global amnesia/Internal jugular vein/Brachiocephalic veins/Transverse sinus hypoplasia/Valsalva maneuver引用本文复制引用
韩珂,赵雅琴,张丰基,钟芷萍,许弘毅,盛文鸯,吴江,胡汉华..静脉回流障碍与短暂性全面遗忘症的相关性[J].中国卒中杂志,2016,11(7):547-555,9.
