中国卒中杂志2016，Vol.11Issue(8)：642-648,7.DOI:10.3969/j.issn.1673-5765.2016.08.007
单侧孤立基底节区腔隙性脑梗死早期神经功能恶化的多因素分析及缺血耐受的相关性研究
The Multi-factors Analysis of Early Neurological Deterioration in Patients with Unilateral Isolated Basal Ganglia Lacunar Cerebral Infarction and the Correlation Study of Ischemia Tolerance
摘要
Abstract
Objective To investigate the related factors of early neurological deterioration (END) in patients with unilateral isolated basal ganglia lacunar cerebral infarction and the related mechanism of brain ischemic tolerance (BIT) and END. <br> Methods Retrospective analysis were made upon clinical data of 167 patients who were diagnosed with unilateral isolated basal ganglia lacunar cerebral infarction conifrmed by magnetic resonance imaging (MRI) excluding artery stenosis diagnosed. According to the score of National Institutes of Health Stroke Scale (NIHSS) of the stroke within 1 week, 167 patients were divided into two groups: positive END and negative END. Multivariate logistic regression analysis was associated to analyze factors related to the early neurologic deterioration of cerebral infarction. <br> Results Among 167 patients, 42 (25.15%) patients suffered END and 125 patients didn’t have END. Multiple factor analysis indicated that lesions located in the internal capsule hind legs radial posterior lateral ventricle were independent risk factors for END and there were signiifcant difference between two groups (P<0.01). The age of onset, history of cerebral infarction, history of diabetes, systolic blood pressure at admission and lesions of cerebral white matter were associated with END, which had significant differences (P<0.05). Single factor and multi-factors analysis of with or without diabetes and difference lesion location at different layer and inter-layers showed that with or without diabetes and difference lesion location didn’t affect the association between age, history of stroke, white matter and positive ENT. END correlates with previous history of stroke, pathological changes of white matter, and age of onset, which had signiifcant difference (P<0.05). <br> Conclusion END in patients with unilateral isolated basal ganglia lacunar cerebral infarction is closely related to the lesion, other related factors such as lesions of cerebral white matter, history of cerebral infarction, history of diabetes and age, etc. Age of 65 years old and above, systolic hypertension, history of stroke, and lesions cerebral white matter are protective factors for positive END. Brain ischemia intolerance is the main mechanism for END.关键词
腔隙性脑梗死/危险因素/脑缺血耐受Key words
Lacunar infarction/Risk factor/Brain ischemic tolerance引用本文复制引用
蔄红好,毕玉华,于永鹏,王胜武,赵振铭,乔晓红,鞠卫萍..单侧孤立基底节区腔隙性脑梗死早期神经功能恶化的多因素分析及缺血耐受的相关性研究[J].中国卒中杂志,2016,11(8):642-648,7.基金项目
国家自然科学基金 （）
