磁共振成像2016，Vol.7Issue(8)：582-586,5.DOI:10.12015/issn.1674-8034.2016.08.005
注意缺陷多动障碍患儿脑结构和功能磁共振成像研究
A study of brain structural and functional magnetic resonance imaging in children with attention deifcit hyperactivity disorder
摘要
Abstract
Objective:To investigate the structural and functional brain changes in ADHD children using MRI.Materials and Methods:Ten ADHD children and 10 matched healthy controls underwent whole brain MRI scans on a GE 1.5 T scanner. High resolution 3-dimensional T1 weighted images and resting-state functional MRI were acquired. From MRI data, parametric maps (the volume maps of gray/white matter tissues and ALFF) were computed in standard toolkits, and group comparisons were performed in SPM8 using a voxel-based approach.Results:Compared with healthy controls, children with ADHD showed decrease of gray matter volumes in the bilateral mid-frontal cortex, precentral cortex, anterior cingulate cortex, putamen, and left orbitofrontal cortex and right caudate and cerebellum, decrease of white matter volumes in the bilateral prefrontal gyrus, anterior and posterior of corpus callosum and left orbitofrontal gyrus, and increased ALFF in bilateral anterior cingulate cortex, right mid- and superior-frontal cortex.Conclusion:ADHD is associated with both structural and functional deifcits in brain development. High resolution 3D T1WI and rs-fMRI provides complementary neuropathological information underlying ADHD.关键词
注意缺陷多动障碍/磁共振成像/脑/磁共振成像,功能/儿童Key words
Attention deficit hyperactivity disorder/Magnetic resonance imaging/Brain/Magnetic resonance imaging, functional/Child分类
医药卫生引用本文复制引用
谢娜,孙龙伟,徐守军,曾伟彬..注意缺陷多动障碍患儿脑结构和功能磁共振成像研究[J].磁共振成像,2016,7(8):582-586,5.基金项目
深圳市科技研发资金项目(编号JCYJ20130401114111467)；深圳市卫生科研项目(编号201303267)ACKNOWLEDGMENTS This work was part of Shenzhen science and technology research and development fund project(No. JCYJ20130401114111467) （编号JCYJ20130401114111467）
Shenzhen health science and research project(No.201303267) （No.201303267）
