大学化学2016，Vol.31Issue(8)：86-88,3.DOI:10.3866/PKU.DXHX201510008
2,4-二甲基吡咯-3,5-二羧酸二乙酯的合成--推荐一个大学有机化学实验
Synthesis of Diethyl 2,4-dimethyl-pyrrole-3,5-dicarboxylate:Recommending a University Organic Chemistry Experiment
摘要
Abstract
Using Knorr pyrrole synthesis, diethyl 2,4-dimethyl-pyrrole-3,5-dicarboxylate was synthesized via one-pot method with ethyl acetoacetate and sodium nitrite as starting materials in the presence of acetic acid and zinc powder. The experiment involves the experimental operation and analyses including temperature control, reflux, recrystal ization, melting point, IR and NMR spectroscopies. The advantages of the experiment are simple raw materials and high product yield. The experiment is helpful for cultivating and improving the synthesis ability of students, as wel as in-depth understanding of heterocyclic synthesis and spectral analysis.关键词
乙酰乙酸乙酯/吡咯/Knorr合成法/一锅法Key words
Ethyl acetoacetate/Pyrrole/Knorr synthesis/One-pot method分类
化学化工引用本文复制引用
汪剑波,宗乾收,沈锦锦,毕成,吴晨俊..2,4-二甲基吡咯-3,5-二羧酸二乙酯的合成--推荐一个大学有机化学实验[J].大学化学,2016,31(8):86-88,3.基金项目
浙江省自然科学基金项目(LQ15B060005)；嘉兴学院教学改革项目(70115030) （LQ15B060005）
