南方医科大学学报2016，Vol.36Issue(8)：1041-1047,7.DOI:10.3969/j.issn.1673-4254.2016.08.03
慢性腰背痛患者的大脑灰质异常：基于体素的形态测量学分析
Brain gray matter abnormalities revealed by voxel-based morphometry in patients with chronic low back pain
摘要
Abstract
Objective To explore the morphometric abnormalities of brain gray matter (GM) in patients with chronic low back pain (CLBP). Methods Thirty patients with CLBP and 30 healthy individuals were enrolled and examined with a 3.0 T magnetic resonance (MR) scanner. High-resolution T1 structural MR data were acquired and data analysis was performed using voxel-based morphometry (VBM) in FMRIB Software Library. The morphological differences were compared between the two groups. Results Compared with the healthy control subjects, patients with CLBP showed decreased GM volumes in several brain cortical areas including the bilateral superior frontal gyrus, right frontal pole, left insular cortex, left middle and left inferior temporal gyrus (P<0.05, after TFCE correction). Increased GM volumes were found in the patients in the subcortical structures including the left thalamus, bilateral putamen, bilateral nucleus accumben and right caudate nucleus (P<0.05, after TFCE correction). Conclusion Patients with CLBP have different patterns of GM abnormalities in different brain regions, characterized by reduced GM volume in cerebral cortical regions and increased GM volume in the subcortical nuclei. Such changes might be associated with the maladaptation of the brain in chronic pain state.关键词
慢性腰背痛/基于体素的形态学/灰质/萎缩/皮层Key words
chronic low back pain/voxel-based morphometry/gray matter/atrophy/cortex引用本文复制引用
毛翠平,杨全新,唐鉴,杨花娟,白芝兰,张秋娟,Zahid Nadeem..慢性腰背痛患者的大脑灰质异常：基于体素的形态测量学分析[J].南方医科大学学报,2016,36(8):1041-1047,7.基金项目
国家自然科学基金（81501455）Supported by National Natural Science Foundation of China (81501455) （81501455）
