南方医科大学学报2016，Vol.36Issue(8)：1134-1139,6.DOI:10.3969/j.issn.1673-4254.2016.08.19
肝细胞癌患者外周血循环肿瘤细胞阳性提示预后不良
Positive circulating tumor cells in the peripheral blood may indicate a poor prognosis in patients with hepatocellular carcinoma
摘要
Abstract
Objective To assess the value of detecting peripheral blood circulating tumor cells (CTCs) in the diagnosis and treatment of hepatocellular carcinoma (HCC). Methods A total of 296 patients diagnosed with HCC admitted in our department from July 2013 to January 2015 were analyzed, with 39 patients with benign liver disease serving as the control group. The distribution of CTCs in the peripheral blood of HCC patients were detected by CanPatrolTM CTCs, and its relationship with the clinical features and prognosis of the patients were analyzed. Results CTCs were detected in 64.5%(191/296) of the HCC patients but in none of the control group (P<0.05). Positive CTCs in peripheral blood of HCC patients were significantly correlated with serum AFP level, tumor number, TNM stage, BCLC stage, portal vein tumor thrombus and metastasis (P<0.05). In 127 HCC patients receiving radical surgery, the patients positive for CTCs showed significantly shorter relapse-free survival time (P<0.05). Conclusion Positive CTCs in the peripheral blood may indicate a poor prognosis in HCC patients. CTCs may serve as a indicator for monitoring the prognosis of HCC.关键词
肝细胞癌/循环肿瘤细胞/外周血/临床病理参数/CanPatrolTMKey words
carcinoma/hepatocellular/circulating tumor cells/peripheral blood/clinical features/CanPatrolTM引用本文复制引用
郭柏棠,刘新城,黄毓,区活辉,李湘竑,杨定华..肝细胞癌患者外周血循环肿瘤细胞阳性提示预后不良[J].南方医科大学学报,2016,36(8):1134-1139,6.基金项目
广东省科技计划项目 （）
