南方医科大学学报2016，Vol.36Issue(8)：1153-1156,4.DOI:10.3969/j.issn.1673-4254.2016.08.23
c-met蛋白与食管鳞状细胞癌的临床分期及细胞分化程度的相关性
Predictive value of c-met for long-term mortality in patients with esophageal squamous cell carcinoma
摘要
Abstract
Objective To explore the correlation of c-met protein with the clinical staging and cell differentiation of esophageal squamous cell carcinoma (ESCC). Methods A total of 100 patients with ESCC were enrolled were examined for expression of c-met protein using immunohistochemistry, and the patients in negative and positive c-met expression groups were compared for clinicopathological characteristics and overall survival. Results The 100 ESCC patients included 67 male and 33 female patients with a median age of 59 years;49 of the patients were negative and 51 were positive for c-met expression. Positive c-met expression was significantly correlated with advanced TMN stages and lower tumor differentiation. Kaplan-Meier survival curve showed that the median survival time of c-met-positive patients was significantly reduced compared with that of c-met-negative patients (30.9 vs 48.2 months, P<0.05). COX regression analysis showed that c-met was a independent risk factor for the overall survival of the patients (HR:2.34, 95%CI:1.63-4.54, P<0.05). Conclusion A positive expression of c-met protein is significantly correlated with an advanced TMN stage, lower tumor differentiation and a poor prognosis, and may serve as a indicator for predicting the prognosis of ESCC.关键词
c-met蛋白/食管鳞癌/临床病理特征/预测Key words
c-met/esophageal squamous cellcarcinoma/clinicopathological features/predictive factors引用本文复制引用
周子浩,陈刚,谢至,唐继鸣,贲晓松,谢亮,周海榆,张冬坤,叶雄..c-met蛋白与食管鳞状细胞癌的临床分期及细胞分化程度的相关性[J].南方医科大学学报,2016,36(8):1153-1156,4.基金项目
广东省自然科学基金 （）
