南方医科大学学报2016，Vol.36Issue(8)：1157-1159,1168,4.DOI:10.3969/j.issn.1673-4254.2016.08.24
非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及其临床意义
Variations of peripheral blood autoantibody, immunoglobuliln, and complement levels in patients with non-lactational mastitis and their clinical significances
摘要
Abstract
Objective To detect the variations in peripheral blood levels of autoantibodies, immunoglobulilns and complements in patients with non-lactational mastitis and investigate whether non-lactational mastitis is an autoimmune disease with immune dysfunction. Methods Seven-eight patients with non-lactational mastitis treated in our hospital between September 2013 and May 2015 and 88 healthy women (control) were examined for peripheral blood levels of antinuclear antibody (ANA), anti-histone antibody (AHA), immunoglobulins (IgA, IgM, and IgG) and complements (C3, C4, and total complements). Results Of the 78 patients with non-lactational mastitis, 50 (64.10%) were positive of ANA showing mainly the granular and cytoplasmic granular fluorescence patterns, and the positivity rate was significantly higher than that in the control group (P<0.000). Twenty-eight (36.00%) of the patients were positive of AHA, a rate significantly higher than that in the control group (P<0.000). The levels of IgA, IgM, C4, and total complements levels were all significantly elevated in the patients compared with those in the control group (P<0.05). Conclusion Patients with non-lactational mastitis have abnormal changes in peripheral blood levels of immunoglobulins and complements with high positivity rates for ANA and AHA, indicating that non-lactational mastitis is an autoimmune disease with immune dysfunction.关键词
非哺乳期乳腺炎/抗核抗体/抗组蛋白抗体/免疫球蛋白/补体Key words
non-lactational mastitis/antinuclear antibody/anti-histone antibody/immunoglobulins/complement system引用本文复制引用
许锐,郭倩倩,杨乐平,赖米林,佟琳..非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及其临床意义[J].南方医科大学学报,2016,36(8):1157-1159,1168,4.基金项目
2013年度广东省中医药局基金 （）
