海南医学院学报2016，Vol.22Issue(16)：1786-1788,1791,4.DOI:10.13210/j.cnki.jhmu.20160513.010
血清胰岛素样生长因子相关指标及白细胞介素与妊娠高血压疾病的关系研究
Study of the relationship of serum insul in-l ike growth factor-related indicators and interleu-kins with pregnancy-induced hypertension
摘要
Abstract
Objective:To study the relationship of serum insulin-like growth factor-related indicators and interleukins with pregnancy-induced hypertension.Methods:A total of 34 patients with gestational hypertension,27 patients with mild pre-eclampsia,18 patients with severe preeclampsia and 50 healthy women were selected as the research subjects,serum was col-lected to determine serum insulin-like growth factor (IGF)-Ⅰ,IGF-Ⅱ,insulin-like growth factor binding proteins (IGFBP)-1,interleukin (IL)-6,IL-8 and IL-18 content,and the placenta was collect to determine IGF-Ⅰ,IGF-Ⅱ,IGFBP-1,IL-6,IL-8 and IL-18 content.Results:IGF-Ⅰ and IGF-Ⅱ levels in placenta tissue and serum of gestational hypertension group,mild preeclampsia group and severe preeclampsia group were significantly lower than those of control group,and IGFBP-1,IL-6, IL-8 and IL-18 levels were significantly higher than those of control group (P <0.05);serum IGF-Ⅰ and IGF-Ⅱ levels were negatively correlated with IL-6,IL-8 and IL-18 levels,and serum IGFBP-1 level was positively correlated with IL-6,IL-8 and IL-18 levels (P <0.05).Conclusions:Decreased serum IGF-Ⅰ,IGF-Ⅱ levels and increased serum IGFBP-1,IL-6,IL-8 and IL-18 levels are associated with pregnancy-induced hypertension,and decreased IGF-Ⅰ and IGF-Ⅱ levels and increased IGFBP-1 level are closely related to increased levels of interleukins.关键词
妊娠高血压疾病/胰岛素样生长因子(IGF)/胰岛素样生长因子结合蛋白(IGFBP)/白细胞介素Key words
Pregnancy-induced hypertension/Insulin-like growth factor/Insulin-like growth factor-binding protein/Interleukin分类
医药卫生引用本文复制引用
米娜瓦尔•艾则孜..血清胰岛素样生长因子相关指标及白细胞介素与妊娠高血压疾病的关系研究[J].海南医学院学报,2016,22(16):1786-1788,1791,4.基金项目
新疆维吾尔自治区科技攻关计划(2012GG2049)[Foundation Project]:Xinjiang Uygur Autonomous Region Science and Technology Key Project (2012GG2049)． （2012GG2049）
