海南医学院学报2016，Vol.22Issue(16)：1792-1795,1799,5.DOI:10.13210/j.cnki.jhmu.20160329.004
利拉鲁肽与二甲双胍对初发2型糖尿病伴肥胖患者体质情况、代谢和微炎症状态的影响
Effect of liraglutide and metformin on the constitution,metabol ism and micro-inflammatory state in newly diagnosed type 2 diabetic mell itus patients with obesity
摘要
Abstract
Objective:To analyze the effect of liraglutide and metformin on the constitution,metabolism and micro-in-flammatory state in newly diagnosed type 2 diabetic mellitus patients with obesity.Methods:A total of 55 cases of newly diag-nosed type 2 diabetic mellitus patients with obesity were included for study and divided into observation group (n = 30)and control group (n =25)according to different treatment plans.Control group received metformin treatment alone,observation group received liraglutide and metformin treatment,and levels of glucolipid metabolism indicators,body mass index and fi-brinolytic activity-related indicators,micro-inflammation-related signaling pathways,illness-related indicators,etc of two groups were detected after one course of treatment.Results:FPG,GHbA1c,TC,TG and LDL-C values in venous blood of ob-servation group after treatment were lower than those of control group (P <0.05);waistline,hipline and waist-hip ratio of ob-servation group decreased after treatment,TM value was lower than that of control group while t-PA value was higher than that of control group (P <0.05 );TLR4-NF-κB signaling pathway and DAG/PKC signaling pathway downstream TLR4,p-NF-κB p65,DAG and PKC protein expression levels of observation group after treatment were significantly lower than those of control group (P <0.05);serum APN,Nesfatin-1 and ISI values of observation group after treatment were higher than those of control group while LP,Chemerin,RBP4 and FINS values were lower than those of control group (P <0.05).Conclusions:Combined therapy of liraglutide and metformin can significantly improve the constitution of newly diagnosed type 2 diabetic mellitus patients with obesity,optimize the general condition and be expected to improve treatment outcome.关键词
2 型糖尿病伴肥胖/利拉鲁肽/二甲双胍/微炎症Key words
Type 2 diabetic mellitus with obesity/Liraglutide/Metformin/Micro-inflammation分类
医药卫生引用本文复制引用
韩秀平,孙涛,汪丽丽,贺钰梅,张梅,李转霞,李林娟,张永莉..利拉鲁肽与二甲双胍对初发2型糖尿病伴肥胖患者体质情况、代谢和微炎症状态的影响[J].海南医学院学报,2016,22(16):1792-1795,1799,5.基金项目
陕西省科技计划项目(2010k15-03-02)[Foundation Project]:This study was supported by Science and Technology Planning Project of Shaanxi Province (2010k 15-03-02)． （2010k15-03-02）
