海南医学院学报2016，Vol.22Issue(16)：1816-1818,3.DOI:10.13210/j.cnki.jhmu.20160513.017
胸腔镜下与开胸肺叶切除术对非小细胞肺癌患者炎症因子及免疫功能的影响
Effect of video-assisted thoracoscopic surgery and traditional open surgery on the inflamma-tory cytokine and immune function in patients with non-small cell lung carcinoma
摘要
Abstract
Objective:To explore the effect of video-assisted thoracoscopic surgery (VATS)and traditional open surger-y (TOS)on the inflammatory cytokine and immune function in patients with non-small cell lung carcinoma.Methods:A total of 68 patients with non-small cell lung carcinoma were included in the study and divided into VATS group and TOS group ac-cording to different surgical methods with 34 cases in each group.The operation time,intraoperative amount of bleeding,inci-sion length,and lymph node dissection number after operation in the two groups were compared.The levels of serum IL-6 and CRP after operation in the two groups were detected and compared.The immunological function status before and after opera-tion in the two groups was analyzed.Results:The operation time and intraoperative amount of bleeding in VATS group were significantly reduced,and the incision length was significantly shortened when compared with TOS group (P <0.05 ).IgG, CD4 + ,and CD8 + levels,and CD4 +/CD8 + after operation in the two groups were significantly reduced when compared with before treatment,and those in TOS group were significantly lower than those in VATS group (P <0.05 or P <0.01).IL-6 and CRP levels 1d after operation in the two groups were significantly elevated when compared with before operation,and those in TOS group were significantly higher than those in VATS group (P <0.05).IL-6 and CRP levels 5d after operation in VATS group were not significantly different from those before operation (P >0.05),while those in TOS group were significantly ele-vated when compared with before operation (P <0.01).Conclusions:VATS in the treatment of non-small cell lung carcinoma has a significant efficacy,can significantly alleviate the inflammatory reaction,and is beneficial to protect the immunological function.关键词
非小细胞肺癌/全胸腔镜下肺叶切除术(VATS)/开胸肺叶切除术(TOS)/炎症因子/免疫球蛋白/淋巴细胞Key words
Non-small cell lung carcinoma/VATS/TOS/Inflammatory cytokine/Immunoglobulin/Lymphocyte分类
医药卫生引用本文复制引用
吕兵,陶永忠,吴旌,钟斌,罗富超,刘洋,张泽学..胸腔镜下与开胸肺叶切除术对非小细胞肺癌患者炎症因子及免疫功能的影响[J].海南医学院学报,2016,22(16):1816-1818,3.基金项目
重庆涪陵科研课题计划(FLXJ 2012ABB1113)[Foundation Project]:It was supported by Scientific Research Planning Project of Fuling ,Chongqing City (FLXJ 2012ABB1113)． （FLXJ 2012ABB1113）
