海南医学院学报2016，Vol.22Issue(16)：1844-1847,4.DOI:10.13210/j.cnki.jhmu.20160517.007
恩度联合力扑素同步放疗对中晚期宫颈癌患者血清 CYFRA21-1、CEA、SCCA、CA 125、lL-8及免疫细胞水平的影响
Effect of endostar combined with pacl itaxel l iposome and radiotherapy simultaneously on se-rum CYFRA21-1,CEA,SCCA,CA125,lL-8 and T lymphocyte subsets in patients with ad-vanced cervical cancer
摘要
Abstract
Objective:To study the effect of endostar combined with paclitaxel liposome and radiotherapy simultaneous-ly on serum cytokerantin-1 9-fragment antigen 21-1 (CYFRA21-1),carcinoembryonic antigen (CEA),squamous cell carcinoma antigen (SCCA),cancer antigen 125 (CA125),interleukin-8 (IL-8)and T lymphocyte subsets in patients with advanced cervi-cal cancer.Methods:A total of 72 patients with advanced cervical cancer in our hospital from January 2014 to February 201 6 were enrolled in this study.The subjects were divided into control group (n =36)and experiment group (n =36)randomly. The control group were treated with radiotherapy,while the experiment group were treated with endostar combined with pacli-taxel liposome and radiotherapy simultaneously.Three weeks was a period of treatment and the two groups were treated for 4 periods.The serum CYFRA21-1,CEA,SCCA,CA125,IL-8 levels and peripheral blood CD3 + ,CD4 + and CD8 + cells of the two groups before and after treatment were compared.Results:There were no significant differences of the serum CYFRA21-1,CEA,SCCA,CA125,IL-8 levels and peripheral blood CD3 + ,CD4 + and CD8 + cells of the two groups before treatment (P>0.05).The serum CYFRA21-1,CEA,SCCA,CA125 and IL-8 levels of the two groups after treatment were significantly lower than that before treatment (P <0.05),and those levels of experiment group were significantly lower than control group (P <0.05).The peripheral blood CD3 + ,CD4 + cells of the two groups after treatment were significantly lower than that before treatment (P <0.05);CD8 + cells of the two groups after treatment were significantly higher than that before treatment (P <0.05);the ratio change of T lymphocyte subsets in experiment group were significantly better than control group (P <0.05). Conclusions:Endostar combined with paclitaxel liposome and radiotherapy simultaneously can significantly reduce the serum CYFRA21-1,CEA,SCCA,CA125 and IL-8 levels,and improve peripheral blood CD3 + ,CD4 + and CD8 + levels of patients with advanced cervical cancer,so it was worthy clinical application.关键词
恩度/力扑素/放疗/中晚期宫颈癌/细胞角蛋白 19 片段抗原 21-1 (CYFRA21-1)/癌胚抗原Key words
Endostar/Paclitaxel liposome/Radiotherapy/Advanced cervical cancer/CYFRA21-1/CEA/SCCA/CA125/IL-8/T lymphocyte subsets分类
医药卫生引用本文复制引用
杨文静,王璐..恩度联合力扑素同步放疗对中晚期宫颈癌患者血清 CYFRA21-1、CEA、SCCA、CA 125、lL-8及免疫细胞水平的影响[J].海南医学院学报,2016,22(16):1844-1847,4.基金项目
武汉市卫生计生委临床医学科研项目(WX15D59)[Foundation Project]:Clinical Medicine Science Research Project of Wuhan Health and Family Planning Commission (WX15D59)． （WX15D59）
