海南医学院学报2016，Vol.22Issue(16)：1904-1907,4.DOI:10.13210/j.cnki.jhmu.20160513.008
视网膜光凝联合康柏西普玻璃体内注射治疗糖尿病视网膜病变的 RNFL厚度、血清细胞因子含量评估
Evaluation of RNFL thickness and serum cytokine levels after retinal photocoagulation com-bined with intravitreous Conbercept injection treatment of diabetic retinopathy
摘要
Abstract
Objective:To evaluate the effect of retinal photocoagulation combined with intravitreous Conbercept injec-tion in RNFL thickness,serum cytokine levels and other aspects of diabetic retinopathy.Methods:A total of 92 patients with diabetic retinopathy (126 eyes)who received inpatient treatment in our hospital from December,2013 to December 201 5 were included in the study and divided into observation group 46 cases (62 eyes)and control group 46 cases (64 eyes)according to random number table,control group received retinal photocoagulation therapy alone,observation group received retinal photo-coagulation combined with intravitreous Conbercept injection treatment,and then differences in RNFL thickness,hemodynamic indexes,serum levels of cytokines and others were compared between two groups after treatment.Results:Average RNFL thickness of inner optic disc top,bottom,bitamporal and nasal ring area as well as the average full-cycle 360°RNFL thickness of observation group after treatment was less than those of control group (P <0.05);PSV and EDV values of CRA were high-er than those of control group while RI value was lower than that of control group,and PSV,EDV and RI values of CRV were lower than those of control group (P <0.05);serumβ2-GPⅠ,Hcy,VEGF and SDF-1 levels were lower than those of control group while C-peptide and APN levels were higher than those of control group (P <0.05).Conclusions:Retinal photocoagula-tion combined with intravitreous Conbercept injection can significantly reduce the RNFL thickness of the patients with diabetic retinopathy and optimize the retinal hemodynamic status,and helps to improve patients’overall conditions.关键词
糖尿病视网膜病变/视网膜光凝/康柏西普玻璃体内注射Key words
Diabetic retinopathy/Retinal photocoagulation/Intravitreous Conbercept injection分类
医药卫生引用本文复制引用
罗娜..视网膜光凝联合康柏西普玻璃体内注射治疗糖尿病视网膜病变的 RNFL厚度、血清细胞因子含量评估[J].海南医学院学报,2016,22(16):1904-1907,4.基金项目
四川省卫生厅立项课题(140023)[Foundation Project]:This project was supported by Health Department of Sichuan Province (NO．140023)． （140023）
