海南医学院学报2016，Vol.22Issue(17)：1958-1961,4.DOI:10.13210/j.cnki.jhmu.20160601.004
辛伐他汀联合苯磺酸氨氯地平对老年高血压合并高血脂症患者血液流变学、血小板活化的影响
Effects of simvastatin combined with amlodipine besylate on blood rheology and platelet ac-tivation in elderly patients with hypertension compl icated with hyperl ipemia
摘要
Abstract
[ABSTRACT]Objective:To investigate the effects of simvastatin combined with amlodipine besylate on blood rheology and platelet activationin in elderly patients with hypertension complicated with hyperlipemia.Methods:A total of 200 elderly pa-tients with hypertension complicated with hyperlipemia were divided into hypertension group (n =64),hyperlipemia group (n=71)and combined (hypertension complicated with hyperlipemia group (n =65).And alternate period health check-up 100 ca-ses as control group.The hypertension group amlodipine besylate monotherapy,hyperlipidemia group with simvastatin mono-therapy,combined group received simvastatin combined with amlodipine besylate treatment,patients of three groups were treated for 12 weeks.Comparison of 4 groups the blood rheology,platelet activation before and after treatment.Results:After treatment,blood pressure was obviously lower than that before treatment in hypertension and combined group (P <0.05),and the combined group reduced more significantly (P <0.05),blood fat was significantly lower than that before treatment in hy-perlipemia and combined group (P < 0.05 ),and combined group reduced more significantly (P < 0.05 );Before treatment, three groups of indexes of blood rheology (high shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity, fibrinogen and platelet activation index(CD62p and CD63)were significantly higher than those in control group (P <0.05),and the combined group increased more significantly than hypertension and hyperlipidemia group (P < 0.05 );After treatment, blood rheology (high shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity,fibrinogen and platelet ac-tivation index (CD62p and CD63)of hyperlipidemia group and combined group were significantly lower than before treatment (P <0.05),and the combined group were greater reduction in amplitude (P <0.05).Conclusion:Simvastatin combined amlo-dipine besylate therapy can obviously improve the blood pressure,blood fat,blood rheology and blood platelet abnormalities in elderly patients with hypertension complicated with hyperlipemia.关键词
高血压合并高血脂症/辛伐他汀/苯磺酸氨氯地平/血液流变学/血小板活化Key words
Hypertension complicated with hyperlipemia/Simvastatin/Amlodipine besylate/Blood rheology/Platelet activation分类
医药卫生引用本文复制引用
蒋明争,李琼,刘会..辛伐他汀联合苯磺酸氨氯地平对老年高血压合并高血脂症患者血液流变学、血小板活化的影响[J].海南医学院学报,2016,22(17):1958-1961,4.基金项目
重庆市科技攻关计划项目(BARQ2013AC1026)[Foundation Project]:This study was supported by key research project of chongqing science and technology (BARQ2013AC1026)． （BARQ2013AC1026）
