海南医学院学报2016，Vol.22Issue(17)：1976-1978,1982,4.DOI:10.13210/j.cnki.jhmu.20160614.018
子痫前期胎盘中 STAT4和 STAT6表达量与 sFlt-1、ADMA 生成及胎盘缺氧的相关性
Correlation between STAT4 and STAT6 expression levels in preeclampsia placenta with sFlt-1 and ADMA generation as well as placental hypoxia
摘要
Abstract
[ABSTRACT]Objective:To study the correlation of STAT4 and STAT6 expression levels in preeclampsia placenta with soluble fms-like tyrosine kinase-1 (sFlt-1)and asymmetric dimethylarginine (ADMA)generation as well as placental hypoxia. Methods:A total of 40 cases of pregnant women with preeclampsia were selected as preeclampsia group (PE group),40 cases of healthy pregnant women scheduled for delivery in our hospital during the same period were selected as control group.Serum was collected to determine STAT4,STAT6,sFlt-1 and ADMA levels,the placenta was collected to determine STAT4, STAT6,HIF-1αand HSP70 expression,and ultrasonography was conducted to measure uterine spiral artery PI,RI and S/D. Results:STAT4 expression levels in placenta and serum of PE group were significantly higher than those of control group while STAT6 expression levels were significantly lower than those of control group;HSP70 and HIF-1αexpression levels in placenta of PE group were significantly higher than those of control group,positively correlated with STAT4 and negatively correlated with STAT6,sFlt-1 and ADMA levels in serum were significantly higher than those of control group,positively correlated with STAT4 and negatively correlated with STAT6,and uterine spiral artery PI,RI and S/D were significantly higher than those of control group,positively related with STAT4 and negatively correlated with STAT6.Conclusion:High expression of STAT4 and low expression of STAT6 in preeclampsia placenta are closely related to placental hypoxia.关键词
子痫前期/STAT4/STAT6/胎盘缺氧/可溶性血管内皮生长因子受体-1/非对称性二甲基精氨酸Key words
Preeclampsia/STAT4/STAT6/Placental hypoxia/Soluble fms-like tyrosine kinase-1/Asymmetric dim-ethylarginine分类
医药卫生引用本文复制引用
苏冬梅..子痫前期胎盘中 STAT4和 STAT6表达量与 sFlt-1、ADMA 生成及胎盘缺氧的相关性[J].海南医学院学报,2016,22(17):1976-1978,1982,4.基金项目
西藏自治区科技厅自然科学基金资助项目(130627)[Foundation Project]:This study was supported by department of science and technology of Tibet autonomous region (grant No ．130627)． （130627）
