海南医学院学报2016，Vol.22Issue(17)：2007-2010,4.DOI:10.13210/j.cnki.jhmu.20160601.008
天晴依泰联合放射性药物89 SrCl 2治疗对肺癌骨转移病灶生长及临床症状的影响
Effects of zoledronic acid injection combined with radiopharmaceutical 89SrCI2 therapy on the growth and cl inical symptoms of lung cancer bone metastasis
摘要
Abstract
[ABSTRACT]Objective:To find the effect of zoledronic acid injection combined with radiopharmaceutical 89SrCI2 therapy on the growth and clinical symptoms of lung cancer bone metastasis.Methods:102 cases of lung cancer patients with bone me-tastases were included in the study and randomly divided into observation group and control group (n =5 1)according to differ-ent treatment they received.Control group received zoledronic acid injection therapy alone,observation group received zoledron-ic acid injection combined with radiopharmaceutical 89SrCI2 therapy,and then differences in the growth of lung cancer bone metastasis,bone metabolism,tumor markers and alkaline phosphatase,pain score and pain-related mediator levels,etc.were compared between two groups.Results:Number of metastases of observation group after treatment was less than that of con-trol group,and serum bone metabolism indexes OPG,BSP,TRACP-5b,ICTP and BAP levels,serum tumor markers CY-FRA21-1,CEA,NSE,CA125 and BALP levels as well as serum pain-related mediators PGE2,ET-1 and TNF-αlevels were lower than those of control group (P <0.05).Conclusion:Zoledronic acid injection combined with radiopharmaceutical 89SrCI2 therapy can contain the growth of lung cancer bone metastasis,optimize bone metabolism state while alleviate patients'percep-tion of pain.关键词
肺癌骨转移/天晴依泰/8 9 SrCl2Key words
Lung cancer bone metastasis/Zoledronic acid injection/89SrCI2分类
医药卫生引用本文复制引用
朱家伦,邓志勇,杨传周..天晴依泰联合放射性药物89 SrCl 2治疗对肺癌骨转移病灶生长及临床症状的影响[J].海南医学院学报,2016,22(17):2007-2010,4.基金项目
云南省应用基础研究(昆医联合专项)(2013FB170)[Foundation Project]:This study was supported by applied basic research project of Yunnan Province (Kunming medical joint project ,2013FB170)． （昆医联合专项）
