海南医学院学报2016，Vol.22Issue(17)：2015-2018,4.DOI:10.13210/j.cnki.jhmu.20160601.007
多西他赛＋奥沙利铂＋替吉奥与多西他赛＋顺铂＋氟尿嘧啶方案治疗晚期胃癌的对比研究
Effects comparison of docetaxel in combination with oxal iplatin + S-1 and docetaxel in com-bination with cisplatin + fluorouracil on advanced gastric cancer
摘要
Abstract
[ABSTRACT]Objective:To compare the prognosis and serum indexes after treatment of docetaxel in combination with ox-aliplatin + S-1 or docetaxel in combination with cisplatin + fluorouracil on advanced gastric cancer.Methods:A total of 496 patients with advanced gastric cancer who received chemotherapy in our hospital were selected and randomly divided into DSOX group (docetaxel + oxaliplatin + S-1 group)and DCF model group (docetaxel + cisplatin + fluorouracil group),and the progression-free survival (PFS)and overall survival (OS)were followed up;before chemotherapy and after two cycles of chemotherapy,serum was collected to determine ALT,AST,BUN,CR,CRP,CEA,CA1 9-9,CA72-4,VEGF,IGF-1, MMP2,MMP7 and MMP9 levels.Results:Median PFS and median OS of DSOX group were longer than those of DCF group;after chemotherapy,serum ALT,AST,BUN,CR and CRP levels of both groups were higher than those before chemotherapy (P <0.05 )but difference in serum ALT,AST,BUN,CR and CRP levels between two groups were not significant (P >0.05);after chemotherapy,serum CEA,CA1 9-9,CA72-4,VEGF,IGF-1,MMP2,MMP7 and MMP9 levels of both groups were significantly lower than those before chemotherapy (P < 0.05 )and serum CEA,CA1 9-9,CA72-4,VEGF,IGF-1, MMP2,MMP7 and MMP9 levels of DSOX group were significantly lower than those of DCF group (P <0.05 ).Conclusion:DSOX chemotherapy can prolong progression-free survival and overall survival in patients with advanced gastric cancer and has better killing effect on cancer cells and better inhibiting effect on angiogenesis in gastric cancer tissue and cancer cell invasion than DCF chemotherapy.关键词
晚期胃癌/无进展生存时间/总生存时间/肿瘤标志物/血管新生/侵袭Key words
Advanced gastric cancer/Progression-free survival/Overall survival/Tumor markers/Angiogenesis/In-vasion分类
医药卫生引用本文复制引用
李玮,赵鹏..多西他赛＋奥沙利铂＋替吉奥与多西他赛＋顺铂＋氟尿嘧啶方案治疗晚期胃癌的对比研究[J].海南医学院学报,2016,22(17):2015-2018,4.基金项目
中航工业(3201yk201605)[Foundation Project]:This study was supported by The China Aviation Industrial （3201yk201605）
