海南医学院学报2016，Vol.22Issue(17)：2032-2034,2038,4.DOI:10.13210/j.cnki.jhmu.20160602.003
甲状腺癌细针穿刺组织中 BRMS1和 Cx43的表达量及其与肿瘤恶性程度的相关性
BRMS1 and Cx43 expression in fine needle aspiration thyroid cancer tissue and their corre-lation with tumor mal ignancy
摘要
Abstract
[ABSTRACT]Objective:To study the BRMS1 and Cx43 expression in fine needle aspiration thyroid cancer tissue and their correlation with tumor malignancy.Methods:Patients undergoing thyroid fine needle aspiration biopsy in our hospital were se-lected for study,60 patients with thyroid cancer and 60 patients with benign thyroid tumor were screened after pathological di-agnosis,biopsy tissue was collected to determine the expression of BRMS1 and Cx43,and serum specimens were collected to determin Gal-3,CEACAM1,MMP2 and MMP9 content.Results:mRNA levels and positive expression rate of BRMS1 and Cx43 in thyroid cancer tissue were significantly lower than those in benign thyroid tumor tissue;mRNA levels of BRMS1 and Cx43 in thyroid cancer tissue with different pathological types and tumor diameters were not different,mRNA level of Cx43 in thyroid cancer tissue with TNM III-IV stage was significantly lower than that in thyroid cancer tissue with TNM I-II stage, mRNA levels of BRMS1 in thyroid cancer tissue with different TNM stages were not different,and mRNA levels of BRMS1 and Cx43 in thyroid carcinoma tissue with lymph node metastasis were significantly lower than those in thyroid carcinoma tis-sue without lymph node metastasis;serum Gal-3,CEACAM1,MMP2 and MMP9 levels in patients with positive BRMS1 and Cx43 expression in thyroid cancer tissue were significantly lower than those in patients with negative BRMS1 and Cx43 expres-sion in thyroid cancer tissue.Conclusion:Lower expression of BRMS1 and Cx43 in fine needle aspiration thyroid cancer tissue is associated with the distant metastasis and malignant degree of tumor,and lower expression of Cx43 is also associated with the growth of tumor and cancer cell proliferation.关键词
甲状腺癌/乳腺癌转移抑制基因 1/细胞缝隙连接蛋白 43/淋巴结转移Key words
Thyroid cancer/Breast cancer metastasis suppressor 1/Connexin 43/Lymph node metastasis分类
医药卫生引用本文复制引用
盛建国,王斌,刁宗平,曹昆昆,张赛,濮正国..甲状腺癌细针穿刺组织中 BRMS1和 Cx43的表达量及其与肿瘤恶性程度的相关性[J].海南医学院学报,2016,22(17):2032-2034,2038,4.基金项目
上海市卫计委青年项目(20144Y0199)[Foundation Project]:This study was supported by youth programs of Health development planning commission of Shanghai (grant No ．20144 y 0199)． （20144Y0199）
