海南医学院学报2016，Vol.22Issue(17)：2042-2045,4.DOI:10.13210/j.cnki.jhmu.20160415.005
联合检测血清碱性磷酸酶与骨钙素在前列腺癌早期骨转移中的诊断价值
Diagnosis value of serum ALP and osteocalcin in early prostate cancer bone metastasis
摘要
Abstract
[ABSTRACT]Objective:To explore the role and significance of the joint detection of serum alkaline phosphatase (ALP) and osteocalcin in prostate cancer bone metastases.Methods:A total of 87 cases of prostate cancer patients were diagnosed by radionuclide bone imaging,and 5 1 cases of them were included in the bone metastases group,while the other 36 cases were se-lected as the non-metastases group.Serum levels of ALP and osteocalcin of all patients were detected.The sensitivity,specifici-ty,accuracy,likelihood ratio and the predictive value of patients in the two groups were analyzed.The sensitivity and specifici-ty of the combined detection of ALP and osteocalcin and their expression levels in different bone metastases degrees were ana-lyzed.Results:Serum ALP and osteocalcin levels of patients in metastases group were higher than those in non-metastases group and normal control group.In non-metastases group,the ALP level was higher than that in normal control group,while its osteocalcin level was lower than that in control group (P <0.05);The sensitivities of ALP and osteocalcin were 77.2% and 70.6%,respectively,and their specificities were 61.1% and 54.6%,respectively.The sensitivity and specificity became 93.3%and 82.33% in combined detection of ALP and osteocalcin,which was significantly higher than the single detection (P <0.05). The expression levels of ALP and osteocalcin increased with the increase of the metastases degrees (P <0.05 ).Conclusions:Combined detection of ALP and osteocalcin can be used in the early diagnosis of prostate cancer with improved diagnostic effi-ciency.关键词
前列腺癌/碱性磷酸酶/骨钙素/骨转移/早期诊断Key words
Prostate cancer/Alkaline phosphatase/Osteocalcin/Bone metastasis/Early diagnosis分类
医药卫生引用本文复制引用
程宗勇..联合检测血清碱性磷酸酶与骨钙素在前列腺癌早期骨转移中的诊断价值[J].海南医学院学报,2016,22(17):2042-2045,4.基金项目
重庆市卫生科技计划项目(20102328)[Foundation Project]:Supported by Chongqing Health Science and Technology Project (Grant No ．20102328)． （20102328）
