河北医学2016，Vol.22Issue(8)：1238-1241,4.DOI:10.3969/j.issn.1006-6233.2016.08.003
CD44V6在大肠癌组织和外周血表达及其临床意义
Expression and Clinical Significance of CD44V6 in Colorectal Cancer Tissues and Peripheral Blood
摘要
Abstract
Objective: To investigate the expression of CD44V6 in colorectal cancer tissue and eripheral blood, to analyze the relationship between clinical pathological features and prognosis of patients with colorec -tal cancer.Methods: Serum samples in peripheral blood and tissue of colorectal cancer from 57 patients were collected.The expression of CD44V6 was detected by immunohistochemical method (SP) and enzyme linked immunosorbent assay (ELISA).The relationship between the clinical pathological characteristics and the prog -nosis of patients with colorectal cancer were analyzed .Results:The expression of CD44V6 was obviously higher (63.16%) in colorectal cancer tissue than that in the adjacent tissue (10.00%,P =0.002).The expression levels of CD44V6 in serum was 14.62±3.344ng/mL, while that was 3.22±1.65ng /mL in normal control group. There was significant difference between the two groups .There were relationship between the expression of CD44V6 and tumor depth, the degree of differentiation, lymph nodes and pathological degree .Kaplan-Meier survival analysis showed that the 5-year survival rate in CD44V7 high expression group was significantly high -er than that in low expression group (P <0.05) .Conclusions: CD44V67 is highly expressed in colorectal cancer tissues and serum, and may be an indicator for predicting the invasion and metastasis of colorectal cancer.关键词
大肠癌/CD44V6/免疫组化/ELLSAKey words
Colorectal cancer/CD44V6/Immunohistochemistry/ELISA引用本文复制引用
宋云骏,姜林鹤,季世强,黄微,关亚男,许再超,杨金光..CD44V6在大肠癌组织和外周血表达及其临床意义[J].河北医学,2016,22(8):1238-1241,4.基金项目
河北省承德市科学技术研究与发展计划项目， （）
