哈尔滨医药2016，Vol.36Issue(4)：401-402,403,3.
日内瓦毛霉对妊娠烯醇酮的生物转化研究
Bio-Transformation of Pregnenolone by Mucor Genevensis
摘要
Abstract
Microbial transformation of pregnenolone was studied in the Mucor genevensis culture, in which 7α,11α-dihydrox-ypregnenolone and 7α, 11β-dihy droxypregnenolone were given from the metabolites. The biotransformation products were deter-mined by IR,NMR and MS analysis. The results showed that the optimal condition for the biosynthesis of 7α,11α—dihydr-roxy-pregnenolone was as follows: 3.5 %dextrose,1.4% peptone, 0.16% potassium dihydydrogen phosphate, initial pH 4.5. The yield of 7α,11α-dihydroxypregnenolone was 59.2%.关键词
甾体/妊娠烯醇酮/日内瓦毛霉/羟基化Key words
Steroids/Biotransformation/Pregnenolone/Hydroxylation分类
医药卫生引用本文复制引用
孙工兵..日内瓦毛霉对妊娠烯醇酮的生物转化研究[J].哈尔滨医药,2016,36(4):401-402,403,3.基金项目
黑龙江省农垦总局基金资助（HNK12KF-24）,大庆科技局科研项目 （）
