军事医学2016，Vol.40Issue(8)：634-638,5.DOI:10.7644/j.issn.1674-9960.2016.08.004
硫醇修饰的磁性银花纳米粒子SERS基底在氯霉素检测中的应用
Alkanethiol modified magnetic silver flower nanoparticles applied to detection of chloramphenicol
摘要
Abstract
Objective To prepare novel alkanethiol modified magnetic silver flower nanoparticles as SERS substrate to chloramphenicol for Raman detection and to determine their enhancement effect.Methods An alkanethiol was chosen as a surface modifier of the substrate and was self-assembled onto the magnetic silver flower nanoparticle surface.The chloram-phenicol molecules were enriched to the surface of the substrate by hydrophobic interaction and the effect for detection of chloramphenicol SERS signal was enhanced.Results It was found that the 1-hexanethiol-modified SERS substrate was able to lead to stronger enhancement than 1-dodecanethiol and octadecanethiol.Fe3 O4@SiO2-Ag-C6 was used to detect the chloramphenicol (10 -3 -10 -10 mol/L) and chloramphenicol in milk (10 -3 -10 -9 mol/L) by surface-enhanced Raman spectroscopy.The detection limits were 0.1 nmol/L (32 ppt) and 1 nmol/L (323 ppt) respectively.Conclusion Alkanethiol modified magnetic silver flower nanoparticles are a highly active SERS substrate, which can be used for detection of low concentrations of analytical substances.关键词
光谱分析,拉曼/硫醇/磁性/纳米粒子/氯霉素Key words
spectrum analysis,Raman/alkanethiol/magnetic/nanoparticles/chloramphenicol分类
医药卫生引用本文复制引用
李萍,汪崇文,荣振,肖瑞,王升启..硫醇修饰的磁性银花纳米粒子SERS基底在氯霉素检测中的应用[J].军事医学,2016,40(8):634-638,5.基金项目
国家重大科学仪器设备开发专项资助项目 （）
