军事医学2016，Vol.40Issue(8)：691-694,4.DOI:10.7644/j.issn.1674-9960.2016.08.017
HLA-G与肿瘤免疫的相关进展
Correlation between HLA-G and tumor immunity and its advances
陈黎 1董延生 2李敏 1张雯珂 1姚元庆1
作者信息
- 1. 解放军总医院妇产科，北京 100853
- 2. 军事医学科学院毒物药物研究所，北京 100850
- 折叠
摘要
Abstract
HLA-G belongs to non-classical HLA-class Ⅰ genes.It is expressed in the fetal-maternal interface on the extravillous cytotrophoblast and in such immune privilege tissues as the cornea and pancreas.However, under pathological conditions, such as tumor, inflammatory diseases and post transplantation, HLA-G is expressed abnormally.HLA-G can interact with its acceptors or immune cells and suppress the function of immune cells, which facilitates the escape of the surveillance of the human immune system and the consequent damage.In clinical studies,HLA-G is related to some clinical parameters.This review will focus on the expression, function and regulatory mechanisms of HLA-G in cancer immunology.关键词
肿瘤免疫/HLA抗原/免疫逃逸/免疫,细胞/微RNAKey words
tumor immune/HLA antigens/immune escape/immunity,cellular/microRNA分类
医药卫生引用本文复制引用
陈黎,董延生,李敏,张雯珂,姚元庆..HLA-G与肿瘤免疫的相关进展[J].军事医学,2016,40(8):691-694,4.
