中南医学科学杂志2016，Vol.44Issue(4)：421-424,427,5.DOI:10.15972/j.cnki.43-1509/r.2016.04.015
解脲支原体感染对不育男性精液质量及生育能力的影响
Effects of Ureaplasma Urealyticum Infection on the Quality of Semen in Patients of Male Sterility
刘伯龙 1王娟花 2唐正 1张益康 1秦松林1
作者信息
- 1. 南华大学附属第一医院泌尿男科，湖南 衡阳42100
- 2. 湖南环境生物职业技术学院
- 折叠
摘要
Abstract
Objective To evaluate the effects of ureaplasma urealyticum( UU) infection on the quality of semen in patients of male sterility. Methods 298 cases of male sterility diagnosed in this study in our hospital were retrospectivel. The semen was diveided into case group( n=109) and control group ( n=189) accoding to whether or not infected with UU. The semen quality of the two groups were tested,the patients of case group received Azithromycin treatment and follow up for one year.The fertility rate was analyzed in the cases grop. Results Compared with the control group,the total sperm activity,the forward movement rate and survival rate spermatozoa was significantly lower,while sperm concentration between the two groups had no significant difference;The morphology normal rate of sperm in the case group was significantly lower than that in the control group ( P<0.05) ,the abnormal rate of sperm head in the case group was significantly higher,But the sperm deformity index,abnormal sperm index,sperm head deformity rate,central deformity rate and tail deformity rate were not statistically significant between the two groups (P>0.05).Compared with the control group,sperm terminal enzyme ac￣tivity of the case group was significantly lower ( P<0.05) ,but the abnormal rate of sperm terminal enzyme and the seminal plasma elastase was significantly higher (P<0.05).According to plasma elastase,the diagnosis of UU infection of urinary and reproductive tract was 67.8% (95%CI:47.1%~87.4%),and 66.7%(95%CI:43.5%~86.8%),for sensitivity and spe￣cificity with area under the ROC curve of 0.71 (95%CI:0.57~0.86).In the case group,78 cases were treated with azithro￣mycin for 2 weeks and with 1 year follow up, the wife ' s pregnancy rate was significantly higher than that of the control group,and the difference was statistically significant ( HR=2.76,95%CI:1.26 ~ 6.06,P<0.05) . Conclusion Ureaplas￣ma urealyticum infection can affect the quality of semen in patients with sterility,which could be one of the reasons for ste￣rility.Anti treatment of ureaplasma urealyticum can elevated the rate of fertility.关键词
解脲支原体/不育/精液质量/生育能力Key words
ureaplasma urealyticum/infertility/semen quality/fertility分类
医药卫生引用本文复制引用
刘伯龙,王娟花,唐正,张益康,秦松林..解脲支原体感染对不育男性精液质量及生育能力的影响[J].中南医学科学杂志,2016,44(4):421-424,427,5.
