肿瘤预防与治疗2016，Vol.29Issue(4)：199-204,6.DOI:10.3969/j.issn.1674-0904.2016.04.002
量化 DCE-MRI 技术对乳腺良恶性病变诊断价值分析
The Diagnostic Features of Quantitative and Semi-quantitative Parameters Obtained from Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI)in Human Breast Lesions
摘要
Abstract
Objective:To evaluate the quantitative and semi-quantitative parameters of Dynamic Contrast En-hanced MRI (DCE-MRI)based on a certain pharmacokinetic modeling in the diagnosis of human breast lesions.Methods:Forty-two patients with breast lesions were enrolled from June 2015 to Feb.2016.All patients received DCE-MRI examina-tion and were diagnosed pathologically within one week.The following quantitative parameters:volume transfer constant (Ktrans ),rate constant (Kep ),plasma fraction (Vp ),and semi-quantitative parameters:time to peak (TTP),max con-centration (MAX Conc),area under curve (AUC),MAX slope were calculated.The difference of these parameters be-tween malignant and benign breast lesions were calculated and compared by independent t test or nonparametric test. Additionally,ROC analysis was used to assess the diagnostic value of these quantitative and semi-quantitative parameters. Results:The values of Ktrans Max (t =2.228,P =0.033), Ktrans Mean (t =4.092,P <0.001),Kep Mean (Z =2.422, P =0.015),Kep Max (t =2.240,P =0.031),MAX Conc Max (t =3.256,P =0.002),MAX Conc Mean (t =3.460,P =0.001),AUC Max (t =2.250,P =0.034),AUC Mean (t =2.861,P =0.007),MAX Slope Max (t =2.478,P =0.018),MAX Slope Mean (t =2.226,P =0.032)were statistically significantly higher in malignant lesions than those in benign lesions,while the TTP Min (t =-5.145,P <0. 001),TTP Mean (t =-3.818,P <0.001)were obviously shortened in malignant lesions than those in benign lesions. The ROC analysis showed that the Ktrans Mean,Kep Mean,TTP Min,MAX Conc Max,AUC Mean,and MAX Slope Max were valuable in diagnosing malignant lesion from benign lesion.Adopting the maximum Youden’index as the cut-off val-ue,if the cut-off value of Ktrans Mean,Kep Mean,TTP Min,MAX Conc Max,AUC Mean,and MAX Slope Max were 0. 1137,0.0258,0.9065,0.1059,0.1640,and 0.1502 respectively,the sensitivity were 73.33%、73.33%、91.67%、76. 67%、80.00%、80.00%,and the specificity were 100%,83.30%,70.00%,91.70%,66.70%,75.00%,respective-ly.Conclusion:The differential diagnosis of benign and malignant breast lesions in human breast by quantitative and semi-quantitative parameters based on DCE-MRI is of clinical value and relatively high efficiency.It is a promising method as a noninvasive evaluation for microcirculation of breast tumor.关键词
乳腺肿瘤/磁共振成像/动态增强/诊断Key words
Breast Tumor/Magnetic Resonance Imaging/Dynamic Enhancement/Diagnosis分类
医药卫生引用本文复制引用
罗红兵,王闽,周鹏,青浩渺,庞华容,梁珂,许国辉,任静..量化 DCE-MRI 技术对乳腺良恶性病变诊断价值分析[J].肿瘤预防与治疗,2016,29(4):199-204,6.基金项目
四川省卫生厅科学研究项目（编号090545）。 （）
