山西医科大学学报2016，Vol.47Issue(8)：703-705,3.DOI:10.13753/j.issn.1007-6611.2016.08.006
肾脏去交感神经对肥胖型高血压家兔血压及相关神经体液因子的影响
Effects of renal sympathetic denervation on obesity-associated hypertension and related neurohormonal factors in rabbits
摘要
Abstract
Objective To investigate the effects of renal sympathetic denervation on obesity-associated hypertension and related neuro-hormonal factors in rabbits. Methods Forty rabbits were randomly divided into four groups:control group, control+ablation group, obesity group and obesity+ablation group. Rabbits in control group and control+ablation group were fed by common diet, and rabbits in obesity group and obesity+ablation group were fed by high energy diet. After feeding for eight weeks, RSD was carried out by transabdominal radiofrequency ablation of renal arterial adventitia. Then rabbits were continuously fed for eight weeks, and then blood pressure was measured. Plasma concentrations of norepinephrine( NE) , arginine vasopressin( AVP) , angiotensinⅡ( AngⅡ) and al-dosterone( ALD) were determined by enzyme-linked immunosorbent assay( ELISA) . Results Compared with control group, the sys-tolic blood pressure(SBP) showed no significant change in obesity+ablation group(P>0. 05). After RSD,the SBP in obesity+abla-tion group was significantly lower than in obesity group(P<0. 05). Compared with control group, plasma concentrations of NE, AVP, Ang II and Ald were significantly decreased in obesity group(P<0. 05). Compared with obesity group, plasma concentrations of NE, AVP, Ang II and Ald in obesity+ablation group were declined significantly after RSD(P<0. 05). Conclusion RSD can reduce the blood pressure of obesity-associated hypertension, and reduce the levels of NE, Ang II, AVP and Ald.关键词
肥胖型高血压/肾脏去交感神经支配术/神经体液因子/兔Key words
obesity-associated hypertension/renal sympathetic denervation/neurohormonal factor/rabbits分类
医药卫生引用本文复制引用
王彬,王海昌,薛玉生,范博渊,尚福军..肾脏去交感神经对肥胖型高血压家兔血压及相关神经体液因子的影响[J].山西医科大学学报,2016,47(8):703-705,3.基金项目
陕西省卫生厅科研基金项目资助(2012D72) （2012D72）
