山西医科大学学报2016，Vol.47Issue(8)：737-741,5.DOI:10.13753/j.issn.1007-6611.2016.08.014
结缔组织病相关肺纤维化、未分化结缔组织病相关肺纤维化和特发性肺纤维化特征分析
Comparison of characteristics of connective tissue disease-associated pulmonary fibrosis, undifferentiated connective tissue disease-associated pulmonary fibrosis,and idiopathic pulmonary fibrosis
摘要
Abstract
Objective To compare the characteristics of connective tissue disease-associated pulmonary fibrosis(CTD-PF), undiffer-entiated connective tissue disease-associated pulmonary fibrosis( UCTD-PF) and idiopathic pulmonary fibrosis( IPF) . Methods Pa-tients with pulmonary fibrosis( PF) in Xijing Hospital from January 2015 to December 2015 were selected in this study,and the PF pa-tients with other known causes were excluded. The clinical manifestation, autoantibody serology, chest high resolution CT, blood gas a-nalysis and other characteristics were retrospectively analyzed. Results A total of 414 patients were enrolled in this study including 226 cases(54. 6%) of CTD-PF, 50 cases(12. 1%) of UCTD-PF and 138 cases (33. 3%) of IPF. The mean age of CTD-PF, UCTD-PF and IPF was 54. 4,57. 6 and 66. 8 years, respectively. The female accounted for 70. 8%,62. 0% and 21. 0% in CTD-PF, UCTD-PF and IPF patients, respectively. Smoking was more common in IPF patients than in CTD-PF, UCTD-PF patients. Varieties of autoanti-bodies were seen in CTD-PF group and UCTD-PF group, but the prevalence of each autoantibody in UCTD-PF group was fewer than in CTD-PF group. Only antinuclear antibody, anti-SSA antibody and anti-Ro-52 antibody were found in IPF group, and the other au-toantibodies were seldom seen in IPF. The inflammatory nodules were the common features in CTD-PF and UCTD-PF patients, while the honeycomb, pulmonary bulla and emphysema were the most frequent features in IPF group. In addition, the prevalences of pulmo-nary infection and respiratory failure were higher in IPF patients than in the other patients. Conclusion Patients with CTD-PF, UCTD-PF and IPF have some similar characteristics, but they show distinct features. The lung manifestation may be more serious in IPF patients than those in CTD-PF and UCTD-PF patients. Thus the overall assessment of PF, especially the autoantibodies monitor, will be conducive to the differential diagnosis of PF and proper treatment.关键词
肺纤维化/结缔组织病/未分化结缔组织病/特发性肺纤维化Key words
pulmonary fibrosis/connective tissue disease/undifferentiated connective tissue disease/idiopathic pulmonary fibrosis分类
医药卫生引用本文复制引用
谢荣华,杨西超,庞琳烜,郑朝晖,朱平..结缔组织病相关肺纤维化、未分化结缔组织病相关肺纤维化和特发性肺纤维化特征分析[J].山西医科大学学报,2016,47(8):737-741,5.基金项目
国家科技重大专项基金资助项目(2014ZX09508002-002) （2014ZX09508002-002）
