山西医科大学学报2016，Vol.47Issue(8)：742-746,5.DOI:10.13753/j.issn.1007-6611.2016.08.015
K-ras、Livin在不同胃黏膜病变中的表达及临床意义
Expression of K-ras, Livin in different gastric mucosa lesions and its clinical significance
摘要
Abstract
Objective To explore the expression of K-ras and Livin in different gastric mucosa lesions and evaluate its role in occur-rence, development and prognosis of gastric cancer. Methods Expression of K-ras and Livin was detected in 90 cases of gastric cancer,30 cases of high-grade intraepithelial neoplasia,30 cases of low-grade intraepithelial neoplasia,30 cases of intestinal metaplasia, 30 cases of superficial gastritis,30 cases of normal gastric mucosa using SP method. The correlation between expression of K-ras and Livin and clinical pathological features was analyzed. Results ①The positive expression rate of K-ras and Livin increased in superfi-cial gastritis, intestinal metaplasia, intraepithelial neoplasia and gastric cancer(0,23. 3%,28. 3%,68. 9%,P<0. 001; 0,13. 3%, 23. 3%,57. 8%,P<0. 001). The positive expression rates of K-ras and Livin were lower in low-grade intraepithelial neoplasia than in intestinal metaplasia(13. 3% vs 23. 3%;10. 0% vs 13. 3%),but there was no significant difference among low-grade intraepithelial neo-plasia, intestinal metaplasia,superficial gastritis and normal gastric mucosa(13. 3%,23. 3%,0,6. 7%,P>0. 05;10. 0%,13. 3%,0, 13. 3%,P>0. 05), while the positive expression rates of K-ras and Livin high-grade intraepithelial neoplasia were significantly higher than low-grade intraepithelial neoplasia(43. 3% vs 13. 3%,P<0. 05;36. 7% vs 10. 0%,P<0. 05). ②The expression rates of K-ras and Livin were both significantly higher in gastric cancer than in low-grade intraepithelial neoplasia, intestinal metaplasia, superficial gas-tritis and normal gastric mucosa(P<0. 01) and high-grade intraepithelial neoplasia(P<0. 05). The expression rate of K-ras and Livin was closely related with age, degree of differentiation, tumor invasion depth and lymph node metastasis(P<0. 05). ③The expression of K-ras in 240 cases of different gastric mucosa lesions was positively correlated with Livin(P<0. 001). The incidences of stage T3 -T4 of tumor invasion depth and lymph node metastasis were the highest in cases of K-ras(+) and Livin(+) and significantly higher than that in cases of K-ras(-) and Livin(-)(P<0. 05). Conclusion The expression of Livin and K-ras is related to the development and progno-sis of gastric cancer,both can be used as ideal tumor markers for early diagnosing gastric cancer and warning metastasis.关键词
胃肿瘤/K-ras/Livin/免疫组织化学Key words
gastric carcinoma/K-ras/Livin/immunohistochemisty分类
医药卫生引用本文复制引用
孟加榕,唐忠辉,温路生,刘美莲,黄仲庆,禹乐..K-ras、Livin在不同胃黏膜病变中的表达及临床意义[J].山西医科大学学报,2016,47(8):742-746,5.基金项目
福建省教育厅A类科技基金资助项目(JA12436) （JA12436）
