中国组织工程研究2016，Vol.20Issue(32)：4811-4817,7.DOI:10.3969/j.issn.2095-4344.2016.32.015
脂肪间充质干细胞移植治疗肝功能衰竭
Adipose-derived mesenchymal stem cell transplantation for treatment of liver failure
胡晓阳 1冷辉国 1毛翠艳 1张远2
作者信息
- 1. 青岛市胶州中心医院特检科，山东省青岛市 266300
- 2. 青岛大学医学院附属医院肝胆外科，山东省青岛市 266000
- 折叠
摘要
Abstract
BACKGROUND:Studies have found that both bone marrow mesenchymal stem cels and umbilical cord mesenchymal stem cels have therapeutic effects on liver failure, but little is reported on adipose-derived mesenchymal stem cel transplantation for treatment of liver failure. <br> OBJECTIVE:To discuss the therapeutic effect of adipose-derived mesenchymal stem cel transplantation on rat liver failure. <br> METHODS: Forty-five Sprague-Dawley rats were equaly randomized into transplantation, model and control group. Except the control group, animal models of liver failure were made by intraperitoneal injection of D-galactosaminein in the transplantation and model groups. One week after modeling, rats in the transplantation group were given 1 mL of adipose-derived mesenchymal stem celsvia the tail vein. <br> RESULTS AND CONCLUSION:Adipose-derived mesenchymal stem cell transplantation successfully upregulated alanine aminotransferase and aspartate aminotransferase levels, and moreover, neatly arranged liver cells, reduced inflammatory cells and intact hepatic lobule were shown on B ultrasound after cell transplantation. All these findings indicate that adipose-derived mesenchymal stem cell transplantation has therapeutic effects on rat liver failure by improving rat’s liver function and pathological changes.关键词
干细胞/移植/脂肪间充质干细胞/肝功能衰竭/B超/肝功能/丙氨酸转氨酶/天门冬氨酸氨基转移酶分类
医药卫生引用本文复制引用
胡晓阳,冷辉国,毛翠艳,张远..脂肪间充质干细胞移植治疗肝功能衰竭[J].中国组织工程研究,2016,20(32):4811-4817,7.
