现代医药卫生2016，Vol.32Issue(16)：2456-2458,3.DOI:10.3969/j.issn.1009-5519.2016.16.002
血清IL-1与G-CSF在胎膜早破亚临床羊膜腔感染诊断中的临床意义
Clinical significance of serum levels of IL-1 and G-CSF in diagnosis of premature rupture of membranes with subclinical amniotic cavity infection
摘要
Abstract
Objective To investigate the clinical significance of serum interleukin-1(IL-1) and granulocyte colony-stim-ulating factor(G-CSF) in premature rupture of membrane(PROM) and histological chorioamnionitis(HCA). Methods A total of 36 full term pregnant women with PROM and without symptoms in our hospital from July to December 2011 were selected as the research group and 50 cases of pregnant women with normal delivery were selected as the control group;the immunohistochemical method was adopted to simultaneously examine the embryonic membrane at the edge of fetal membrane rupture for determining HCA. The pregnant women with HCA by fetal membrane histopathological examination were taken as the HCA group and non-HCA as the non-HCA group. The levels of IL-1 and G-CSF were detected by enzyme linked immunosorbent assay (ELISA). Results (1)The HCA occurrence rate in the research group was 63.89%(23/36),which was higher than 4.00%(2/50) in the control group,the difference was statistically significant(P<0.05);(2)the levels of serum IL-1 and G-CSF in the research group were higher than those in the control group with statistical difference (P<0.05);(3)the levels of IL-1 and G-CSF in the HCA group were higher than those in the non-HCA group,the differences were statistically significant(P<0.05). Conclusion The increase of IL-1 and G-CSF levels has certain clinical significance in the aspect of PROM complicating HCA ,and their combined detection is conducive to early prediction and diagnosis.关键词
白细胞介素1/粒细胞集落刺激因子/胎膜早破/绒毛膜羊膜炎Key words
Interleukin-1/Granulocyte colony-stimulating factor/Fetal membranes,premature rupture/Chorioamnionitis引用本文复制引用
李雪莲,罗永红,汪洋,田正华,李霞,初晓丽..血清IL-1与G-CSF在胎膜早破亚临床羊膜腔感染诊断中的临床意义[J].现代医药卫生,2016,32(16):2456-2458,3.基金项目
深圳市宝安区科技局项目（20110490）。 （）
