烟草科技2016，Vol.49Issue(8)：57-63,7.DOI:10.16135/j.issn1002-0861.2015.0537
液相色谱-串联质谱法测定烟用纸张中3种异噻唑啉酮类杀菌剂
Determination of 3 isothiazolinone biocides in paper for cigarette by liquid chromatography-tandem mass spectrometry
摘要
Abstract
In order to accurately determine the residues of isothiazolinone biocides in paper for cigarette (cigarette paper,plug wrap,inner liner and tipping paper),a rapid liquid chromatography-tandem mass spectrometry(LC-MS/MS)method for determining three isothiazolinone biocides (2-methyl-4-isothiazolin-3-one,5-chloro-2-methyl-4-isothiazolin-3-one and 1,2-benzylisothiazolin-3-one)was developed. The paper sample was ultrasonically extracted with methanol, then the extract was centrifuged, the supernatant liquid was filtrated and then injected into LC-MS/MS and separated in a fluorine phenyl column by using methanol-water as mobile phase. The analytes were detected by LC-MS/MS under multiple reaction monitoring mode and quantified by an internal standard method. The results displayed that the recoveries of the proposed method ranged from 89.1% to 110.8%,and the relative standard deviations were not higher than 7.1% for all analytes. The LODs and LOQs were 0.014-0.018 and 0.045-0.059 mg/kg,respectively. This method is simple,accurate and suitable for the qualitative and quantitative analysis of trace isothiazolinone biocides in paper for cigarette.关键词
液相色谱-串联质谱法/烟用纸张/异噻唑啉酮类杀菌剂Key words
Liquid chromatography-tandem mass spectrometry/Paper for cigarette/Isothiazolinone biocide分类
轻工纺织引用本文复制引用
周晓,叶长文,李小兰,范忠,陈志燕,李栋,周芸,王维刚..液相色谱-串联质谱法测定烟用纸张中3种异噻唑啉酮类杀菌剂[J].烟草科技,2016,49(8):57-63,7.基金项目
国家烟草专卖局标准项目“烟用材料中异噻唑啉酮类杀菌剂残留量及迁移量分析研究”（2014QB011）。 （）
