针刺研究2016，Vol.41Issue(4)：369-372,4.DOI:10.13702/j.1000-0607.2016.04.017
神经胶质细胞在电针治疗神经病理性疼痛中的作用研究进展
Involvement of Central Neuroglia Cells in Analgesic Effect of Electroacupuncture Therapy for Neuropathic Pain
摘要
Abstract
Neuropathic pain is one of the common chronic syndromes in clinical practice.It has been demonstrated that the chronic neuropathic pain and glial cells in the central nervous system are closely related to each other.When inducing analge-sic effect in neuropathic pain,EA suppressed OX-42 labeled activation of microgliacytes in dorsal horns of the spinal cord,down-regulated release of nitric oxide (NO),expression of P 2 X4 receptor,intracellular mitogen-activated protein kinase (MAPK),ex-tracellular regulated protein kinases (ERK),proinflammatory cytokines IL-1 β,IL-6,TNF-α,interferon (IF)-γ and up-regulated neurotrophin-3 expression in neuropathic pain rats.In regard to spinal astrocytes,acupuncture suppressed peripheral nerve injury induced activation of GFAP-labeled astrocytes,down-regulated the expression levels of macrophage inflammatory proteins (MI P)-1 ,MI P-1 β,MI P-3 α,TNF-α mRNA and IL-1 βmRNA,etc.in the dorsal horns of the spinal cord.Up to now,the underlying me-chanisms of acupuncture in regulating activities of glia cells,and interaction between neurons and glia cells,and the related path-ways in the peripheral and central systems remain unclear.The effects of some related protein and gene expressions involving in acupuncture analgesia need being confirmed by adopting different approaches.关键词
神经病理性疼痛/电针镇痛/神经胶质细胞/综述Key words
Neuropathic pain/Electroacupuncture analgesia/Glial cells/Review分类
医药卫生引用本文复制引用
李思思,屠文展,钟燕彪,姜霞,蒋松鹤..神经胶质细胞在电针治疗神经病理性疼痛中的作用研究进展[J].针刺研究,2016,41(4):369-372,4.基金项目
项目来源:国家自然科学基金(No.81574074) （No.81574074）
