中国病理生理杂志2016，Vol.32Issue(8)：1466-1470,5.DOI:10.3969/j.issn.1000-4718.2016.08.022
鹿茸水提物减轻顺铂所致的小鼠肾损伤
Protective effect of aqueous extract of velvet antler on cisplatin-induced nephrotoxicity in mice
摘要
Abstract
AIM:To study the protective effect of aqueous extract of 2-branched and 3-branched velvet antler on cisplatin (CDDP)-induced nephrotoxicity in mice .METHODS:The mouse model of renal injury was induced by intra-gastric administration of CDDP at the dose of 15 mg/kg.After treatment, kidney index (KI), serum creatinine (SCr), blood urea nitrogen (BUN), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the content of malondialdehyde ( MDA) in the kidney were determined .The renal pathological changes were observed with HE staining.RESULTS:Aqueous extract of velvet antler at the tested dose markedly decreased BUN , SCr and the content of MDA, and elevated the activity of SOD and GSH-Px in the mice pretreated with CDDP ( P<0.05) .The pathological chan-ges of the renal tissues were improved obviously , and the injury of the epithelial cells of renal tubules was mitigated .The effect of the aqueous extract of 2-branched velvet antler on renal function and cisplatin-induced nephrotoxicity was better than that of 3-branched one at the same concentration .CONCLUSION: The aqueous extract of 2-branched and 3-branched velvet antler has a certain protective effect on cisplatin-induced nephrotoxicity , which may be associated with in-creasing the anti-oxidative capability of mouse renal tissue .关键词
鹿茸水提物/顺铂/肾毒性/抗氧化作用Key words
Aqueous extract of velvet antler/Cisplatin/Nephrotoxicity/Anti-oxidation分类
医药卫生引用本文复制引用
董思敏,王海璐,王全凯,张晶..鹿茸水提物减轻顺铂所致的小鼠肾损伤[J].中国病理生理杂志,2016,32(8):1466-1470,5.基金项目
吉林省科技计划发展项目 （）
