中国普通外科杂志2016，Vol.25Issue(8)：1180-1185,6.DOI:10.3978/j.issn.1005-6947.2016.08.016
肝切除术后第3天ICG-R15对肝细胞肝癌术后肝功能不全的预测价值
Value of ICG-R15 on postoperative day3 in predicting liver dysfunction after hepatectomy for hepatocellular carcinoma
梅理祥 1李增博 1谢艳会 1王栋 1周乐杜1
作者信息
- 1. 中南大学湘雅医院 普通外科，湖南 长沙410008
- 折叠
摘要
Abstract
Objective: To investigate the value of indocyanine green retention test at 15 minutes (ICG-R15) on postoperative day (POD) 3 in predicting the occurrence of liver dysfunction atfer hepatectomy for hepatocellular carcinoma (HCC). <br> Methods: hTe clinical data of 119 HCC patients undergoing hepatectomy from January 2015 to February 2016 were reviewed. The relations of the occurrence of postoperative liver dysfunction with preoperative and POD 3 ICG-R15 were analyzed, and the difference in predicting the occurrence of postoperative liver dysfunction between preoperative and POD 3 ICG-R15 was also compared. <br> Results: Postoperative liver dysfunction occurred in 33 (27.7%) of the 119 patients. In patients with and without liver dysfunction, the average preoperative ICG-R15 was 9.7% and 5.2%, and POD 3 ICG-R15 was 11.8% and 5.3% respectively, and either the preoperative or POD 3 ICG-R15 was signiifcantly different between patients with and without liver dysfunction (bothP<0.05). Results of stratiifed analysis showed that the incidence of postoperative liver dysfunction was increased with the elevation of either preoperative or POD 3 ICG-R15, with statistical difference noted between patients with ICG-R15<10% and >20% (bothP<0.05). hTe area under the curve of ROC of POD 3 ICG-R15 for prediction of preoperative liver dysfunction was larger than that of preoperative ICG-R15, and the cut-off value for the former was 7.75 (sensitivity: 66.7%; speciifcity: 83.7%) and for the latter was 3.35 (sensitivity: 84.8%; speciifcity: 46.5%), respectively. <br> Conclusion: POD 3 ICG-R15 can be used for predicting liver dysfunction atfer hepatectomy for HCC similar to that of preoperative ICG-R15, and may even be superior to the latter.关键词
癌,肝细胞/肝切除术/肝功能不全/吲哚花青绿Key words
Carcinoma, Hepatocellular/Hepatectomy/Hepatic Insuffciency/Indocyanine Green分类
医药卫生引用本文复制引用
梅理祥,李增博,谢艳会,王栋,周乐杜..肝切除术后第3天ICG-R15对肝细胞肝癌术后肝功能不全的预测价值[J].中国普通外科杂志,2016,25(8):1180-1185,6.
