中国循证儿科杂志2016，Vol.11Issue(4)：241-246,6.DOI:10.3969/j.issn.1673-5501.2016.04.001
中国西部单中心二级医院呼吸道感染住院患儿鼻咽部肺炎链球菌携带及其血清型和耐药性的横断面调查
摘要
Abstract
Objective To investigate the status of nasopharyngeal carriage rate,serotype distribution and antibiotic resistance pattern of Streptococcus pneumoniae isolates collected from children with respiratory tract infections inpatiented in Youyang county. Methods The nasopharyngeal swab was collected from children with respiratory tract infections inpatiented in People′s Hospital of Chongqing Youyang County from January to December in 2015. The serotype was determined by Quellung reaction,and the antibiotic susceptibility was tested by E-test method and disc diffusion. Results The nasopharyngeal carriage rate of Streptococcus pneumoniae was 25. 3%(267/1054),major in winter and spring among children younger than 5 years old. Serotype 19F(47, 17. 6%),6A(35,13. 1%),14(31,11. 6%),19A(28,10. 5%),23F(28,10. 5%)and 6B(25,9. 4%)were the common serotypes,and the coverage rate of 13-pneumococcal conjugate vaccine(PCV13)was 73. 8%(197/267). All of the isolates were sensitive to ceftriaxone,vancomycin and levofloxacin. The sensitive rates to linezolid,imipenem and telithromycin were 96. 3%, 87. 5% and 84. 5%,respectively. All of the isolates were sensitive to penicillin using the parenteral breakpoints,but the sensitive rate was just 16. 9% according to the oral breakpoints. 99. 3%(135/136)of the isolates were resistant to erythromycin and azithromycin. The non-suscepibility rates to oral penicillin,cefepime,cefuroxime and imipenem were higher in PCV13 isolates than non-PCV13 isolates(P<0. 01). Isolates of serotype 19A were more resistant than the other serotype isolates. Conclusion The nasopharyngeal carriage rate of Streptococcus pneumoniae was 25. 3%,the common serotypes were 19F,6A,14,19A,23F and 6B. PCV13 coverage rate was high,and the non-suscepibility rates to oral penicillin,cefepime,cefuroxime and imipenem were higher in PCV13 isolates than non-PCV13 isolates.关键词
肺炎链球菌/儿童/血清型/耐药性/肺炎链球菌结合疫苗Key words
Streptococcus pneumoniae/Children/Serotype/Antibiotic resistance/PCV引用本文复制引用
陈长会,史伟,彭拥军,熊维,袁林,高薇,程小平,姚开虎..中国西部单中心二级医院呼吸道感染住院患儿鼻咽部肺炎链球菌携带及其血清型和耐药性的横断面调查[J].中国循证儿科杂志,2016,11(4):241-246,6.基金项目
国家自然科学基金81371853；国家科学技术部项目2013BAI09B11；北京市科委行业定额经费自主项目2016-bjsekyjs-3 （）
