中国药房2016，Vol.27Issue(23)：3172-3174,3.DOI:10.6039/j.issn.1001-0408.2016.23.02
阿司匹林抵抗的基因多态性及个体化治疗
Gene Polymorphism of Aspirin Resistance and Individualized Treatment
摘要
Abstract
OBJECTIVE:To provide theoretical foundation for individualized treatment of aspirin in patients with cardiovascu-lar disease. METHODS:Domestic and foreign literatures in recent years were collected and summarized. RESULTS & CONCLU-SIONS:The gene polymorphism can significantly affect the platelet activity. GPIII a PLA2,PEAR1 and PTGS1 alleles are associat-ed with aspirin resistance,and cardiovascular events have significant difference in different genotype patients. Adjusting reasonably dosage regimen and conducting individualized treatment according to the genetic testing result and other factors can reduce aspirin resistance and the incidence of cardiovascular adverse events in the patients.关键词
阿司匹林抵抗/基因多态性/个体化治疗Key words
Aspirin resistance/Gene polymorphism/Individualized treatment分类
医药卫生引用本文复制引用
彭文星,冯频频,石秀锦,仇琪,杜海燕,林阳..阿司匹林抵抗的基因多态性及个体化治疗[J].中国药房,2016,27(23):3172-3174,3.基金项目
“重大新药创制”科技重大专项课题 （）
