中国药房2016，Vol.27Issue(23)：3200-3203,3204,5.DOI:10.6039/j.issn.1001-0408.2016.23.11
我院2012－2015年抗菌药物使用与细菌耐药率的相关性分析
Analysis of Association between Antibiotic Use and Bacterial Resistance Rate in Our Hospital during 2012-2015
摘要
Abstract
OBJECTIVE:To provide reference for clinical rational use of antibiotics. METHODS:The use of antibiotics in our hospital from Jan. 2012 to Dec. 2015 was analyzed,the DDDs was calculated,bacterial resistance rates over the same period was analyzed,and the relationship between them were analyzed with Pearson method. RESULTS:During 2012-2015,the top 3 antibiot-ic DDDs in our hospital were cephalosporins,macrolides and quinolones;bacterial with the top 5 detection rate was Escherichia co-li,Pseudomonas aeruginosa,Klebsiella pneumoniae,Acinetobacter Bauman and Staphylococcus aureus;the DDDs of imipenem cilastatin sodium showed a positive correlation with the resistance rate of P. aeruginosa(r=0.95,P<0.05)and the total resistance rate of Gram-negative bacteria (r=0.98,P<0.05),meropenem showed a positive correlation with the resistance rate of K. pneu-moniae(r=0.97,P<0.05),piperacillin sulbactam sodium showed a negative correlation with the resistance of P. aeruginosa(r=-0.98,P<0.05). CONCLUSIONS:DDDs is correlated with the antibiotic drug resistance rate of bacteria,which should be planned and scientific used to reduce the bacterial resistance.关键词
抗菌药物/耐药率/用药频度/相关性Key words
Antibacterial drug/Drug resistance/DDDs/Correlation分类
医药卫生引用本文复制引用
韩凤昭,李振知..我院2012－2015年抗菌药物使用与细菌耐药率的相关性分析[J].中国药房,2016,27(23):3200-3203,3204,5.
