摘要
Abstract
Objective To analyze the clinical effect of salmeterol/fluticasone propionate combined with tiotropium bromide in treatment of elderly patients with chronic obstructive pulmonary disease.Methods 86 cases of elderly patients with COPD cured in our hospital were randomly divided into observation group and control group with 43 cases in each.Patients in observation group were treated with salmeterol/fluticasone propionate combined with tiotropium bromide,and patients in control group were treated with salbutamol combined with tiotropium bromide. Pulmonary function indexes of patients,6 minute walk distance (6MWD),dyspnea score (MMRC) and index of inflammatory factors of the two groups were detected separately before treatment and 28 days after treatment.Results After treatment,the levels of FVC,FEV1 and FEV1/FVC in the two groups were higher than those before treatment (P<0.05).Elevation of each index in observation group were all higher than those of control group (P<0.05).6MWD in the two groups were increased compared with before treatment (P<0.05).MMRC scores in the two groups were decreased compared with before treatment (P<0.05).Improvement range of each index in observation group were all bigger than those of control group (P<0.05).At the same time,after treatment,the index level of IL-8,hs-CRP,TNF-αin the two groups were all decreased compared with before treatment (P<0.05).The decline range of each index in observation group were all bigger than those of control group (P<0.05). Conclusion The clinical effect of salmeterol/fluticasone propionate combined with tiotropium bromide in treatment of elderly patients with COPD is significant with recommendations for clinical promotion and application.关键词
慢性阻塞性肺疾病/老年/沙美特罗/丙酸氟替卡松/噻托溴铵Key words
Chronic obstructive pulmonary disease/Elderly patients/Salmeterol/Fluticasone propionate/Tiotropium bromide分类
医药卫生
