中国医院用药评价与分析2016，Vol.16Issue(8)：1038-1039,1040,3.DOI:10.14009/j.issn.1672-2124.2016.08.011
苦参素注射液对结直肠癌化疗患者白细胞及肝肾功能的影响
Effects of Oxymatrine Injection on Leukocyte and Hepatorenal and Kidney Function of Colorectal Cancer Patients with Chemotherapy
周佳敏 1程绪 2廖毅3
作者信息
- 1. 四川护理职业学院药学系，四川成都 610100
- 2. 四川护理职业学院附属医院药剂科，四川成都 610100
- 3. 四川大学华西医院腹部肿瘤科，四川成都 610041
- 折叠
摘要
Abstract
OBJECTIVE:To probe into the effects of oxymatrine injection on leukocyte and hepatorenal and kidney function of colorectal cancer patients with chemotherapy.METHODS:196 patients with colorectal cancer admitted from Jan. 2012 to Dec.2015 were selected to be divided into observation group and control group via the random number table. 102 patients in control group were treated with oxaliplatin +calcium folinate +fluorouracil ( FOLFOX4 ) chemotherapy combined with oxymatrine injection, while 94 patients in control group were given single FOLFOX4 chemotherapy; the treatment course was 6 cycles in both groups.Changes of blood routine, hepatorenal and kidney function were compared between two groups.RESULTS: The blood platelet count and numeration of leukocyte in observation group decreased compared with before treatment,and the decrease of control group was more significant than that of observation group, with statistically significant difference(P<0.05).And the hepatorenal function in both groups had no obvious change, there was no statistical significance between two groups before and after treatment ( P >0.05 ) .The serum creatinine level of observation group was lower than that of control group, with statistically significant difference(P<0.05).CONCLUSIONS:The effects of oxymatrine injection on leukocyte and hepatorenal and kidney function of colorectal cancer patients with chemotherapy is significant, which can help to reduce the toxicity of chemotherapy in patients.关键词
恶性肿瘤/苦参素/化疗/肝功能/肾功能Key words
Colorectal cancer/Oxymatrine injection/Chemotherapy/Hepatorenal function/Kidney function分类
医药卫生引用本文复制引用
周佳敏,程绪,廖毅..苦参素注射液对结直肠癌化疗患者白细胞及肝肾功能的影响[J].中国医院用药评价与分析,2016,16(8):1038-1039,1040,3.
