化工进展2016，Vol.35Issue(8)：2329-2333,5.DOI:10.16085/j.issn.1000-6613.2016.08.04
缬沙坦在乙酸乙酯中的溶解度及介稳区
Solubility and metastable zone of valsartan in ethyl acetate
王清清 1孙勤 1杨阿三 1程榕 1郑燕萍1
作者信息
- 1. 浙江工业大学化学工程学院，浙江杭州 310014
- 折叠
摘要
Abstract
The solubility of valsartan in ethyl acetate was measured by a static equilibrium method at temperatures from 278.15K to 323.15K. The solubility data were correlated by the modified Apelblat equation,the NRTL equation,and theλhequation. In addition,the thermodynamic parameters (including the enthalpy,entropy and Gibbs energy) were calculated by the van’t Hoff analysis. The results showed that the solubility of valsartan obviously increased with an increase of temperature. The experimental data were well correlated with the above models because the mean deviation values of these three models were 1.03%,3.87%,and 1.7%,respectively. Therefore,the modified Apelblat equation was the best choice in the correlation of the solubility data of valsartan. The values of thermodynamic parameters proved that the dissolution process of valsartan in ethyl acetate was endothermic,spontaneous and entropy-driven. The main contributor to the standard molar Gibbs energy of solution was the enthalpy change during the dissolution process. Furthermore,the supersolubility of valsartan in ethyl acetate was measured at different stirring rates and cooling rates by the laser method. The results indicated that the metastable zone was wider under the condition of low stirring rate,high temperature and large cooling rate. Meanwhile,the temperature effect was remarkable but the cooling rate had little effect on the metastable zone.关键词
缬沙坦/乙酸乙酯/溶解度/超溶解度/介稳区Key words
valsartan/ethyl acetate/solubility/correlation/metastable zone分类
数理科学引用本文复制引用
王清清,孙勤,杨阿三,程榕,郑燕萍..缬沙坦在乙酸乙酯中的溶解度及介稳区[J].化工进展,2016,35(8):2329-2333,5.
