检验医学与临床2016，Vol.13Issue(15)：2078-2081,4.DOI:10.3969/j.issn.1672-9455.2016.15.003
髓过氧化物酶指数与革兰阴性菌脓毒症的关系
Relation between myeloperoxidase index and Gram-negative bacterial sepsis
摘要
Abstract
Objective To monitor the changes of inflammatory parameters in sepsis patients ,especially the change of myeloper‐oxidase index (M PXI ) for differentiating the sepsis diagnosis and bacterial types .Methods One‐hundred and eighty‐three patients with bacterial infections were divided into the local infection group ,systemic inflammatory response syndrome (SIRS) group and sepsis group .Fifty‐four individuals undergoing healthy physical examination served as the control group .The inflammation situation at admission ,on 1 ,5 ,10 d after admission was detected for conducting the comparative analysis .Results The inflammatory status at admission was obviously different from various groups ,MPXI in the patients with local infection and sepsis was decreased;the in‐flammatory indicators in other patients were increased ,the differences were statistically significant(P< 0 .05);MPXI began to change on 1 d in the patients with sepsis and SIRS ,procalcitonin(PCT ) in the inflammatory patients began to increase on 5 d;the specificity and sensitivity of MPXI predicting Gram‐negative bacterial sepsis infection at admission were 62 .1% and 70 .3% respec‐tively ,the optimal critical point was -2 .1 .Conclusion MPXI is decreased in sepsis patients ,which can serve as differentiation of sepsis diagnosis and infected bacterial type .关键词
革兰阴性菌脓毒症/髓过氧化物酶/细菌感染Key words
Gram-negative sepsis/myeloperoxidase/bacterial infection引用本文复制引用
邹国英,任碧琼,贺军宇,徐国锋,徐飞..髓过氧化物酶指数与革兰阴性菌脓毒症的关系[J].检验医学与临床,2016,13(15):2078-2081,4.基金项目
湖南省卫生和计生委科研基金课题（B2014-103）；湖南省科技厅资助项目（2013SK-3215）；湖南省脑科医院重点专科资助项目（2015）。 （）
