检验医学与临床2016，Vol.13Issue(15)：2092-2094,3.DOI:10.3969/j.issn.1672-9455.2016.15.008
3种血清标志物检测在桥本甲状腺炎中的诊断探讨
Study on value of 3 serum markers detection in diagnosing Hashimoto′s thyroiditis
摘要
Abstract
Objective To study the clinical diagnostic significance of the three antibodies levels including thyroid peroxidase anti‐body(anti‐TPO) ,thyroglobulin antibody(anti‐Tg) and thyrotropin receptor antibody(TRAb) in Hashimoto′s thyroiditis .Methods Totally 89 patients with Hashimoto′s thyroiditis(HT) in our hospital from Jan .2014 to Dec .2015 were collected .The patients were divided into the thyroid hypothyroidism group(HT1 ,21 cases) ,hyperthyroidism group(HT2 ,9 cases) ,euthyroidism group (HT3 , 59 cases) ,Graves disease group(GD ,35 cases) and simple nodular goiter (SG ,40 cases) according to the thyroid function .Eighty individuals undergoing the physical examination in our hospital were selected as the healthy control group ,including 18 males and 62 females .The electricity chemiluminescence immunoassay (CLIA) was used to measure the anti‐TPO ,anti‐Tg and TRAb levels in these five groups and the obtained data were statistically analyzed .Results The anti‐TPO ,anti‐Tg and TRAb levels and positive rates had statistical differences among different diseases(P<0 .05);in the patients with Hashimoto′s thyroiditis ,the anti‐TPO level in the HT1 group was higher than that in the HT2 and HT3 group(P<0 .05) ,while the anti‐Tg level had no statistical difference among the HT1 ,HT2 and HT3 groups ,the anti‐TPO and anti‐Tg levels in the HT group were higher than those in the GD group , the GD group was higher than the SG group and healthy control group ,the differences were statistically significant(P<0 .05) ,but the difference between the SG group and the healthy control group had no statistical significance(P>0 .05) .The TRAb positive rate was highest in the GD group ,which had statistical difference between the GD group and the other 4 groups(P<0 .05) .Conclu‐sion The combined detection of anti‐TPO and anti‐TG is an important indicator for diagnosing Hashimoto′s thyroiditis and TRAB has an important significance to the differential diagnosis of Hashimoto′s Thyroiditis and Graves disease .关键词
桥本甲状腺炎/甲状腺自身抗体/甲状腺过氧化物酶抗体/甲状腺球蛋白抗体/促甲状腺激素受体抗体Key words
Hashimoto′s thyroiditis/thyroid autoantibodies/thyroid peroxidase antibody/thyroglobulin antibody/thy-rotropin receptor antibodies引用本文复制引用
梁修珍,刘芳,糜晓梅,杨晓琼,麻慧磊..3种血清标志物检测在桥本甲状腺炎中的诊断探讨[J].检验医学与临床,2016,13(15):2092-2094,3.基金项目
重庆市卫生和计划生育委员会医学科研基金项目（2015MSXM142）。 （）
