检验医学与临床2016，Vol.13Issue(15)：2097-2099,3.DOI:10.3969/j.issn.1672-9455.2016.15.010
前列地尔联合α-硫辛酸治疗糖尿病周围神经病变的临床研究
Clinical study of alprostadil combined withα-lipoic acid in treating diabetic peripheral neuropathy
摘要
Abstract
Objective To investigate the effect and action mechanism of alprostadil combined with α‐lipoic acid in the treatment of diabetic peripheral neuropathy(DPN) to provide the scientific basis for its clinical application .Methods Totally 50 patients with DPN were selected and randomly divided into the treatment group and control group .The two groups were given the conventional controlling blood sugar therapy .The control group was given methylcobalamin ,while the treatment group was treated with alpros‐tadil combinedα‐lipoic acid ,for 14 d .The clinical symptom assessment before and after treatment ,lower extremity nerve conduction velocity (NCV) and vibration perception threshold (VPT) were recorded in the two groups .Serum high‐sensitivity C‐reactive pro‐tein(hs‐CRP) ,malondialdehyde (MDA) and superoxide dismutase (SOD) levels were detected .Results After 14 d treatment ,the clinical efficacy of the treatment group not only was superior to that of the control group ,but also NCV was significantly increased and VPT was significantly decreased ,the differences were statistically significant(P<0 .05);compared with the control group ,hs‐CRP and MDA levels in the treatment group were significantly decreased ,while the SOD activity was significantly increased ,the differences were statistically significant (P<0 .05) .Conclusion Alprostadil combined with α‐lipoic acid can significantly improve the clinical effect in the patients with DNP as well as increase NCV and decrease VPT ,its mechanism may realized by increasing an‐tioxidant capacity and reducing inflammatory reaction .关键词
前列地尔/α-硫辛酸/糖尿病周围神经病变/氧化应激Key words
alprostadil/α-lipoic acid/diabetic peripheral neuropathy/oxidative stress引用本文复制引用
王艳红,岳宗相,黄荣利,钟振东,谢春光..前列地尔联合α-硫辛酸治疗糖尿病周围神经病变的临床研究[J].检验医学与临床,2016,13(15):2097-2099,3.基金项目
四川省眉山市科技局项目（2014）。 （）
