检验医学与临床2016，Vol.13Issue(15)：2103-2105,2108,4.DOI:10.3969/j.issn.1672-9455.2016.15.012
小剂量秋水仙碱联合得宝松治疗急性痛风性关节炎的疗效分析
Analysis on effect of low-dose colchicine combined with diprospan for treating acute gouty arthritis
摘要
Abstract
Objective To analyze and summarize the clinical effect and safety of low‐dose colchicine combined with diprospan (compound betamethasone) by intramuscular injection in treating gouty arthritis .Methods The clinical data in 61 cases of acute gouty arthritis in the Daping Hospital of the Third Military Medical University from January 2012 to December 2015 were retro‐spectively analyzed ,in which the treatment group(38 cases) adopted the scheme of low‐dose colchicine combined with single intra‐muscular injection of diprospan and the control group(23 cases) was treated by the large‐dose colchicines scheme .The laboratory indicators such as ESR ,CRP were re‐detected after 1‐week treatment and the improvement situation of joint swelling and pain was evaluated .The clinical effects and adverse reactions were compared between the two groups .Results Compared with before treat‐ment ,the ESR and CRP levels after 1‐week treatment in the treatment group were significantly decreased ,and CRP in the control group was significantly decreased ,the differences were statistically significant(P<0 .05) ,the decrease of ESR level was unobvious without statistical difference(P>0 .05);WBC and NEUT in the two groups were significantly decreased ,the swollen joint count (SJC) ,tender joint count (TJC) ,involved joint count and visual analogue scale (VAS) pain score were significantly decreased , which had statistical differences between the two groups (P< 0 .05) .The ESR and CRP levels after treatment in the treatment group was more significant than that in the control group ,the difference was statistically significant(P< 0 .05) .The situation of SJC ,TJC and involved joints total number and VAS score after treatment had no statistical differences between the two groups(P>0 .05) .The occurrence rate of adverse reactions was 56 .52% in the control group and 15 .79% in the treatment group ,the differ‐ence was statistically significant (P<0 .05) .Conclusion Low‐dose colchicine combined with single intramuscular injection of dipro‐span and large‐dose colchicine all can effectively treat acute gouty arthritis ,but the former has lower occurrence rate of adverse reac‐tions ,better tolerance and high safety .关键词
关节炎 ,痛风性/秋水仙碱/倍他米松/治疗Key words
arthritis ,gouty/colchicine/betamethasone/treatment引用本文复制引用
杨彦龙,李小琴,史静,周颖,何光桥,孙明芳,刘重阳..小剂量秋水仙碱联合得宝松治疗急性痛风性关节炎的疗效分析[J].检验医学与临床,2016,13(15):2103-2105,2108,4.基金项目
重庆市渝中区科技计划项目（20140120）。 （）
